Circulating microRNAs and aerobic fitness--the HUNT-Study

Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent potential early markers of future cardiovascular disease (CVD). The aim of this...

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Published in:PloS one 2013-02, Vol.8 (2), p.e57496-e57496
Main Authors: Bye, Anja, Røsjø, Helge, Aspenes, Stian T, Condorelli, Gianluigi, Omland, Torbjørn, Wisløff, Ulrik
Format: Article
Language:English
Subjects:
Adult
Atherosclerosis
Bioindicators
Biology
Biomarkers
Blood
Blood pressure
Cardiology
Cardiorespiratory fitness
Cardiovascular diseases
Cholesterol
Cohort Studies
Exercise
Female
Fitness
Gene expression
Glucose
Heart attacks
Heart failure
Hospitals
Humans
Hypoxia
Kinases
Male
Medical imaging
Medicine
MicroRNAs
MicroRNAs - blood
miRNA
Mortality
Oxygen
Oxygen Consumption
Oxygen uptake
Physical activity
Physical Fitness
Risk analysis
Risk factors
Signalling systems
Smoking
Target recognition
Triglycerides
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Summary:Aerobic fitness, measured as maximal oxygen uptake (VO2max), is a good indicator of cardiovascular health, and a strong predictor of cardiovascular mortality. Biomarkers associated with low VO2max may therefore represent potential early markers of future cardiovascular disease (CVD). The aim of this study was to assess whether circulating microRNAs (miRs) are associated with VO2max-level in healthy individuals. In a screening study, 720 miRs were measured in serum samples from healthy individuals (40-45 yrs) with high (n = 12) or low (n = 12) VO2max matched for gender, age and physical activity. Candiate miRs were validated in a second cohort of subjects with high (n = 38) or low (n = 38) VO2max. miR-210 and miR-222 were found to be higher in the low VO2max-group (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057496