Effect of calcitriol on bone turnover and osteocalcin in recent-onset type 1 diabetes

Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic contr...

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Bibliographic Details
Published in:PloS one 2013-02, Vol.8 (2), p.e56488-e56488
Main Authors: Napoli, Nicola, Strollo, Rocky, Pitocco, Dario, Bizzarri, Carla, Maddaloni, Ernesto, Maggi, Daria, Manfrini, Silvia, Schwartz, Ann, Pozzilli, Paolo
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age of Onset
Analysis
Biocompatibility
Bone growth
Bone mass
Bone resorption
Bone Resorption - complications
Bone Resorption - drug therapy
Bone Resorption - metabolism
Bone turnover
C-Peptide - blood
Calcitriol
Calcitriol - administration & dosage
Child
Child development
Children
Collagen - blood
College campuses
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - metabolism
Diabetes Mellitus, Type 1 - physiopathology
Endocrinology
Female
Follow-Up Studies
Fractures
Glucose
Glycated Hemoglobin A - metabolism
Glycosylated hemoglobin
Hemoglobin
Humans
Insulin
Insulin - blood
Insulin resistance
Insulin-Secreting Cells - drug effects
Male
Markers
Medicine
Metabolism
Osteocalcin
Osteocalcin - metabolism
Osteogenesis
Osteogenesis - drug effects
Osteoporosis
Pancreas
Patients
Peptide Fragments - blood
Peptides
Plasma
Studies
Supplements
Teenagers
Type 1 diabetes
Type 2 diabetes
Vitamin D
Vitamin D - metabolism
Vitamin deficiency
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Summary:Vitamin D supplementation in childhood improves the achievement of peak bone mass. We investigated the effect of supplementation with calcitriol on bone turnover in recent-onset type 1 diabetes (T1D). Moreover, the association between osteocalcin and parameters of β-cell function and metabolic control was examined. We conducted a post-hoc analysis of a double-blind, placebo-controlled study of calcitriol supplementation to preserve β-cell function. 27 recent-onset T1D subjects, mean age 22 years, were randomized to 0.25 µg calcitriol per day or placebo (1:1) and followed up for one year. Changes in bone formation (osteoclacin) and resorption (beta-CrossLaps) markers, and differences between placebo and calcitriol-treated group were evaluated. At baseline, osteocalcin levels were significantly lower in female than in male patients (P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0056488