A refined study of FCRL genes from a genome-wide association study for Graves' disease

To pinpoint the exact location of the etiological variant/s present at 1q21.1 harboring FCRL1-5 and CD5L genes, we carried out a refined association study in the entire FCRL region in 1,536 patients with Graves' disease (GD) and 1,516 sex-matched controls by imputation analysis, logistic regres...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2013-03, Vol.8 (3), p.e57758-e57758
Main Authors: Zhao, Shuang-Xia, Liu, Wei, Zhan, Ming, Song, Zhi-Yi, Yang, Shao-Ying, Xue, Li-Qiong, Pan, Chun-Ming, Gu, Zhao-Hui, Liu, Bing-Li, Wang, Hai-Ning, Liang, Liming, Liang, Jun, Zhang, Xiao-Mei, Yuan, Guo-Yue, Li, Chang-Gui, Chen, Ming-Dao, Chen, Jia-Lun, Gao, Guan-Qi, Song, Huai-Dong
Format: Article
Language:English
Subjects:
Alleles
Analysis
Autoimmune diseases
B cells
Biology
CD19 antigen
CD8 antigen
Chromosomes, Human, Pair 1
Consortia
Disease control
Disease susceptibility
Endocrinology
Epigenesis, Genetic
Epigenetic inheritance
Etiology
Female
Gene expression
Gene Expression Profiling
Gene Frequency
Genes
Genetics
Genome-wide association studies
Genome-Wide Association Study
Genomes
Genomics
Graves Disease - genetics
Haplotypes
Hospitals
Humans
Immunology
Laboratories
Linkage Disequilibrium
Lymphocytes B
Male
Medical research
Medicine
Metabolism
NF-κB protein
Pathogenesis
Polymorphism, Single Nucleotide
Quantitative Trait Loci
Receptors, Fc - genetics
Regression analysis
Risk analysis
Signaling
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Studies
Thyroid diseases
Transcription (Genetics)
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:To pinpoint the exact location of the etiological variant/s present at 1q21.1 harboring FCRL1-5 and CD5L genes, we carried out a refined association study in the entire FCRL region in 1,536 patients with Graves' disease (GD) and 1,516 sex-matched controls by imputation analysis, logistic regression, and cis-eQTL analysis. Among 516 SNPs with P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0057758