Alteration in endoglin-related angiogenesis in refractory cytopenia with multilineage dysplasia

The functional mechanisms involved in angiogenesis and the potential role of endoglin (ENG), recently described as a new marker for this process, have not been explored in Myelodysplastic Syndromes (MDS). In order to gain insight in MDS angiogenesis a combined analysis in bone marrow (BM) of gene ex...

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Bibliographic Details
Published in:PloS one 2013-01, Vol.8 (1), p.e53624-e53624
Main Authors: del Rey, Mónica, Pericacho, Miguel, Velasco, Soraya, Lumbreras, Eva, López-Novoa, José Miguel, Hernández-Rivas, Jesús María, Rodríguez-Barbero, Alicia
Format: Article
Language:English
Subjects:
Abnormalities
Analysis
Anemia
Anemia, Refractory - metabolism
Anemia, Refractory - pathology
Angiogenesis
Angiogenesis Inducing Agents - metabolism
Antigens, CD - genetics
Antigens, CD - metabolism
Biology
Bone marrow
Bone Marrow - metabolism
Bone Marrow - pathology
Cancer
Cell Lineage
Cell Proliferation
Cellular Microenvironment
Dysplasia
Endoglin
Endothelial cells
Endothelial Cells - metabolism
Endothelial Cells - pathology
Endothelium
Fibronectins
Gene expression
Growth factors
Humans
Leukemia
Leukocytes (mononuclear)
Medical research
Medicine
Mitochondrial DNA
Myelodysplastic syndrome
Myelodysplastic syndromes
Myelodysplastic Syndromes - metabolism
Myelodysplastic Syndromes - pathology
Neovascularization, Pathologic - metabolism
Neovascularization, Pathologic - pathology
Overexpression
Patients
Proteins
Receptors, Cell Surface - genetics
Receptors, Cell Surface - metabolism
Signal transduction
Solubility
Studies
Tumors
Vascular endothelial growth factor
Vascular Endothelial Growth Factor A - genetics
Vascular Endothelial Growth Factor A - metabolism
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Summary:The functional mechanisms involved in angiogenesis and the potential role of endoglin (ENG), recently described as a new marker for this process, have not been explored in Myelodysplastic Syndromes (MDS). In order to gain insight in MDS angiogenesis a combined analysis in bone marrow (BM) of gene expression levels, angiogenesis-related soluble factors and functional angiogenesis-related studies was carried out. Ninety-seven MDS patients and forty-two normal BM samples were studied. The morphology of the capillary-like structures originated by two endothelial cells lines in the BM environment of patients with refractory cytopenia with multilineage dysplasia (RCMD) was different from those of the remaining MDS. In addition, the BM mononuclear cells from RCMD patients displayed over-expression of VEGF, HIF and FN1 while they showed reduced expression of ENG in contrast to the normal ENG expression of the remaining low-risk MDS and the high expression of ENG in high-risk MDS subtype. Moreover, higher soluble ENG and soluble FLT-1 levels in BM microenvironment were observed in RCMD cases, which distinguished them from other individuals. Therefore, the present study suggests that the patterns of angiogenesis are different between the MDS subtypes. The differences in angiogenesis observed in RCMD patients could be related to ENG abnormalities.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0053624