Increased expression of ATG10 in colorectal cancer is associated with lymphovascular invasion and lymph node metastasis

Autophagy has paradoxical and complex functions in cancer development, and autophagy-related genes (ATG) are key regulators in autophagy. Until now, more than 30 different ATG proteins have been identified in yeast, and their mammalian counterparts also have been reported. Although the roles of a fe...

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e52705-e52705
Main Authors: Jo, Yoon Kyung, Kim, Seung Cheol, Park, In Ja, Park, So Jung, Jin, Dong-Hoon, Hong, Seung-Woo, Cho, Dong-Hyung, Kim, Jin Cheon
Format: Article
Language:English
Subjects:
Aged
Analysis
Autophagy
Autophagy-Related Proteins
Binding sites
Biology
Biotechnology
Breast cancer
Cancer
Cancer metastasis
Cell death
Cell Proliferation
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - genetics
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
Deoxyribonucleic acid
Development and progression
Disease
Disease Progression
DNA
DNA methylation
Enzymes
Extracellular matrix
Female
Gastric cancer
Gene Expression Regulation, Neoplastic
Genes
Genomes
Homeostasis
Humans
Lymph
Lymph nodes
Lymph Nodes - pathology
Lymphatic Metastasis
Lymphatic system
Lymphatic Vessels - pathology
Male
Medical prognosis
Medical research
Medicine
Metabolism
Metastases
Metastasis
Middle Aged
Mutation
Neoplasm Staging
Oncology
Patients
Phagocytosis
Proteins
Regulators
Stomach cancer
Surgery
Survival
Tissues
Tumor cell lines
Tumorigenesis
Tumors
Type 2 diabetes
Ubiquitin-Conjugating Enzymes - genetics
Ubiquitin-Conjugating Enzymes - metabolism
Up-Regulation
Vesicular Transport Proteins
Yeast
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Summary:Autophagy has paradoxical and complex functions in cancer development, and autophagy-related genes (ATG) are key regulators in autophagy. Until now, more than 30 different ATG proteins have been identified in yeast, and their mammalian counterparts also have been reported. Although the roles of a few ATG proteins in cancer have been characterized, the role of ATG10 is almost completely unknown. To investigate the clinicopathological role of ATG10 in colorectal cancer, we analyzed ATG10 expression in colorectal cancer tissues and cell lines. Protein expression analysis showed that ATG10 is highly increased in colorectal cancer (tissue - 18/37 cases, 48%; cell line -8/12 cell lines, 66%). Immunohistochemical analysis with clinicopathological features indicated a strong association of the up-regulation of ATG10 with tumor lymph node metastasis (p = 0.005) and invasion (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0052705