Organic solvents as risk factor for autoimmune diseases: a systematic review and meta-analysis

Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exi...

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Bibliographic Details
Published in:PloS one 2012-12, Vol.7 (12), p.e51506
Main Authors: Barragán-Martínez, Carolina, Speck-Hernández, Cesar A, Montoya-Ortiz, Gladis, Mantilla, Rubén D, Anaya, Juan-Manuel, Rojas-Villarraga, Adriana
Format: Article
Language:English
Subjects:
Advertising executives
Autoimmune diseases
Autoimmune Diseases - etiology
Autoimmunity
Biology
Case-Control Studies
Chemical compounds
Chemistry
Clinical medicine
Confidence intervals
Disease
Diseases
Environmental factors
Epigenetic inheritance
Epigenetics
Exposure
Gene expression
Genetic factors
Health risks
Health sciences
Humans
Hydrocarbons
Immune system
Medicine
Meta-analysis
Multiple sclerosis
Nitric oxide
Organic Chemicals - adverse effects
Organic solvents
Review Literature as Topic
Rheumatoid arthritis
Risk analysis
Risk Factors
Scleroderma
Scleroderma (Disease)
Sensitivity analysis
Solvents
Solvents - adverse effects
Studies
Systematic review
Systemic sclerosis
Systemic vasculitis
Toxicology
Vasculitis
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Summary:Genetic and epigenetic factors interacting with the environment over time are the main causes of complex diseases such as autoimmune diseases (ADs). Among the environmental factors are organic solvents (OSs), which are chemical compounds used routinely in commercial industries. Since controversy exists over whether ADs are caused by OSs, a systematic review and meta-analysis were performed to assess the association between OSs and ADs. The systematic search was done in the PubMed, SCOPUS, SciELO and LILACS databases up to February 2012. Any type of study that used accepted classification criteria for ADs and had information about exposure to OSs was selected. Out of a total of 103 articles retrieved, 33 were finally included in the meta-analysis. The final odds ratios (ORs) and 95% confidence intervals (CIs) were obtained by the random effect model. A sensitivity analysis confirmed results were not sensitive to restrictions on the data included. Publication bias was trivial. Exposure to OSs was associated to systemic sclerosis, primary systemic vasculitis and multiple sclerosis individually and also to all the ADs evaluated and taken together as a single trait (OR: 1.54; 95% CI: 1.25-1.92; p-value
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0051506