Epistasis analysis for estrogen metabolic and signaling pathway genes on young ischemic stroke patients

Endogenous estrogens play an important role in the overall cardiocirculatory system. However, there are no studies exploring the hormone metabolism and signaling pathway genes together on ischemic stroke, including sulfotransferase family 1E (SULT1E1), catechol-O-methyl-transferase (COMT), and estro...

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Bibliographic Details
Published in:PloS one 2012-10, Vol.7 (10), p.e47773-e47773
Main Authors: Hsieh, Yi-Chen, Jeng, Jiann-Shing, Lin, Huey-Juan, Hu, Chaur-Jong, Yu, Chia-Chen, Lien, Li-Ming, Peng, Giia-Sheun, Chen, Chin-I, Tang, Sung-Chun, Chi, Nai-Fang, Tseng, Hung-Pin, Chern, Chang-Ming, Hsieh, Fang-I, Bai, Chyi-Huey, Chen, Yi-Rhu, Chiou, Hung-Yi
Format: Article
Language:English
Subjects:
17β-Estradiol
Adult
Atherosclerosis
Biology
Brain Ischemia - genetics
Breast cancer
Cardiovascular disease
Case-Control Studies
Catechin
Catechol
Catechol O-Methyltransferase - genetics
Chromosomes
Consortia
Control methods
Disease susceptibility
Entropy
Enzymes
Epistasis
Estradiol
Estrogen
Estrogen Receptor alpha - genetics
Estrogen receptors
Estrogens
Estrogens - metabolism
Estrone sulfotransferase
Female
Females
Gene polymorphism
Genes
Genetic aspects
Genotype
Genotypes
Haplotypes
Health risks
Hormones
Hospitals
Humans
Ischemia
Male
Medicine
Metabolism
Metabolites
Middle Aged
Multiple regression models
Neurology
Physiological aspects
Polymorphism
Polymorphism, Single Nucleotide
Population
Preeclampsia
Public health
Regression analysis
Regression models
Sex hormones
Signal Transduction
Signaling
Single nucleotide polymorphisms
Single-nucleotide polymorphism
Stroke
Stroke - genetics
Stroke patients
Studies
Sulfotransferase
Sulfotransferases - genetics
Womens health
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Summary:Endogenous estrogens play an important role in the overall cardiocirculatory system. However, there are no studies exploring the hormone metabolism and signaling pathway genes together on ischemic stroke, including sulfotransferase family 1E (SULT1E1), catechol-O-methyl-transferase (COMT), and estrogen receptor α (ESR1). A case-control study was conducted on 305 young ischemic stroke subjects aged
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0047773