The potential of avian H1N1 influenza A viruses to replicate and cause disease in mammalian models

H1N1 viruses in which all gene segments are of avian origin are the most frequent cause of influenza pandemics in humans; therefore, we examined the disease-causing potential of 31 avian H1N1 isolates of American lineage in DBA/2J mice. Thirty of 31 isolates were very virulent, causing respiratory t...

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Bibliographic Details
Published in:PloS one 2012-07, Vol.7 (7), p.e41609-e41609
Main Authors: Koçer, Zeynep A, Krauss, Scott, Stallknecht, David E, Rehg, Jerold E, Webster, Robert G
Format: Article
Language:English
Subjects:
Animal models
Animals
Biology
Disease Models, Animal
Disease transmission
Epidemics
Fatalities
Female
Ferrets - virology
Influenza
Influenza A
Influenza A Virus, H1N1 Subtype - pathogenicity
Influenza A Virus, H1N1 Subtype - physiology
Influenza viruses
Medicine
Mice
Mortality
Orthomyxoviridae Infections - transmission
Orthomyxoviridae Infections - virology
Pandemics
Pathogenicity
Pathogens
Respiratory tract
Respiratory tract diseases
Shedding
Species Specificity
Swine influenza
Veterinary Science
Viral Load
Virulence (Microbiology)
Virus Replication
Viruses
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Summary:H1N1 viruses in which all gene segments are of avian origin are the most frequent cause of influenza pandemics in humans; therefore, we examined the disease-causing potential of 31 avian H1N1 isolates of American lineage in DBA/2J mice. Thirty of 31 isolates were very virulent, causing respiratory tract infection; 22 of 31 resulted in fecal shedding; and 10 of 31 were as pathogenic as the pandemic 2009 H1N1 viruses. Preliminary studies in BALB/cJ mice and ferrets showed that 1 of 4 isolates tested was more pathogenic than the pandemic 2009 H1N1 viruses in BALB/cJ mice, and 1 of 2 strains transmitted both by direct and respiratory-droplet contact in ferrets. Preliminary studies of other avian subtypes (H2, H3, H4, H6, H10, H12) in DBA/2J mice showed lower pathogenicity than the avian H1N1 viruses. These findings suggest that avian H1N1 influenza viruses are unique among influenza A viruses in their potential to infect mammals.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0041609