Circulating thyroxine, thyroid-stimulating hormone, and hypothyroid status and the risk of prostate cancer

Thyroid hormones may influence risk of cancer through their role in cell differentiation, growth, and metabolism. One study of circulating thyroid hormones supports this hypothesis with respect to prostate cancer. We undertook a prospective analysis of thyroid hormones and prostate cancer risk in th...

Full description

Saved in:

Bibliographic Details
Published in:	PloS one 2012-10, Vol.7 (10), p.e47730-e47730
Main Authors:	Mondul, Alison M, Weinstein, Stephanie J, Bosworth, Tracey, Remaley, Alan T, Virtamo, Jarmo, Albanes, Demetrius
Format:	Article
Language:	eng
Subjects:	Aged alpha-Tocopherol - blood Beta carotene beta Carotene - blood Blood banks Cancer Cancer prevention Cancer research Case-Control Studies Cell differentiation Confidence intervals Disease prevention Genetic Association Studies Globulins Health aspects Health risk assessment Health risks Hormones Humans Hypothyroidism Male Medicine Men Metabolism Middle Aged Minority & ethnic groups Oncology, Experimental Physiological aspects Prevention Prostate Prostate cancer Prostatic Neoplasms - blood Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Risk Risk Factors Smokers Smoking Thyroid Thyroid cancer Thyroid Function Tests Thyroid gland Thyroid hormones Thyroid-stimulating hormone Thyrotropin Thyrotropin - blood Thyrotropin - genetics Thyroxine Thyroxine - blood Thyroxine - genetics Tocopherol Tocopherols Vitamin E β-Carotene
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Thyroid hormones may influence risk of cancer through their role in cell differentiation, growth, and metabolism. One study of circulating thyroid hormones supports this hypothesis with respect to prostate cancer. We undertook a prospective analysis of thyroid hormones and prostate cancer risk in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study. Within the ATBC Study, a randomized controlled trial of α-tocopherol and β-carotene supplements and cancer incidence in male smokers, 402 prostate cancer cases were sampled. Controls were matched 2:1 to cases on age and date of blood collection. Odds ratios (OR) and 95% confidence intervals (CI) of prostate cancer were estimated for quintiles of serum total and free thyroxine (T4), thyroid-stimulating hormone (TSH), thyroid-binding globulin (TBG), and by categories of thyroid status. Men with serum higher TSH had a decreased risk of prostate cancer compared to men with lower TSH (Q5 vs. Q1-4: OR = 0.70, 95% CI: 0.51-0.97, p = 0.03). When the T4 and TSH measurements were combined to define men as hypothyroid, euthyroid or hyperthyroid, hypothyroid men had a lower risk of prostate cancer compared to euthyroid men (OR = 0.48, 95% CI = 0.28-0.81, p = 0.006). We observed no association between hyperthyroid status and risk, although the number of hyperthyroid men with prostate cancer was small (n = 9). In this prospective study of smokers, men with elevated TSH and those classified as being in a hypothyroid state were at decreased risk of prostate cancer. Future studies should examine the association in other populations, particularly non-smokers and other racial/ethnic groups.
ISSN:	1932-6203 1932-6203