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Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain
Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic...
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| Published in: | PloS one 2012-10, Vol.7 (10), p.e46114-e46114 |
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| creator | Barretti, Diego Lopes Mendes Magalhães, Flávio de Castro Fernandes, Tiago do Carmo, Everton Crivoi Rosa, Kaleizu Teodoro Irigoyen, Maria Claudia Negrão, Carlos Eduardo Oliveira, Edilamar Menezes |
| description | Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain.
THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured.
The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p |
| doi_str_mv | 10.1371/journal.pone.0046114 |
| format | article |
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THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured.
The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p<0.05), while a tendency was found for OZR versus OZR+EXT (p = 0.07). In addition, exercise reduced (57%) triglycerides and (61%) LDL in the OZR+EXT. The systemic angiotensin I-converting enzyme (ACE) activity did not differ regardless of obesity and EXT, however, the OZR and OZR+EXT showed (66%) and (42%), respectively, less angiotensin II (Ang II) plasma concentration when compared with LZR. Furthermore, the results showed that EXT in the OZR prevented increase in CH, cardiac ACE activity, Ang II and AT2 receptor caused by obesity. In addition, exercise augmented cardiac ACE2 in both training groups.
Despite the unchanged ACE and lower systemic Ang II levels in obesity, the cardiac RAS was increased in OZR and EXT in obese Zucker rats reduced some of the cardiac RAS components and prevented obesity-related CH. These results show that EXT prevented the heart RAS hyperactivity and cardiac maladaptive morphological alterations in obese Zucker rats.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0046114</identifier><identifier>PMID: 23077501</identifier><language>eng</language><publisher>United States: Public Library of Science</publisher><subject>ACE2 ; Aerobic exercises ; Aerobics ; Angiotensin ; Angiotensin I ; Angiotensin II ; Angiotensin II - metabolism ; Angiotensin-converting enzyme 2 ; Animals ; Apoptosis ; Biochemistry ; Biology ; Blood Pressure ; Blotting, Western ; Cardiomyopathy ; Cardiovascular diseases ; Cholesterol ; Complications and side effects ; Echocardiography ; Enzymes ; Exercise ; Fitness training programs ; Health aspects ; Heart - physiopathology ; Heart diseases ; Heart Rate ; High density lipoprotein ; Hyperactivity ; Hypertension ; Hypertrophy ; Laboratories ; Lipoproteins (high density) ; Lipoproteins (low density) ; Low density lipoprotein ; Male ; Medical schools ; Medicine ; Molecular biology ; Myosin Heavy Chains - metabolism ; Obesity ; Obesity - physiopathology ; Peptidyl-dipeptidase A ; Peptidyl-Dipeptidase A - metabolism ; Physical Conditioning, Animal ; Physical education ; Physical fitness ; Physical training ; Physiological aspects ; Rats ; Rats, Zucker ; Real-Time Polymerase Chain Reaction ; Renin ; Renin-Angiotensin System ; Reverse Transcriptase Polymerase Chain Reaction ; Risk factors ; Rodents ; Studies ; Swimming ; Training ; Triglycerides ; Weight control ; Workloads</subject><ispartof>PloS one, 2012-10, Vol.7 (10), p.e46114-e46114</ispartof><rights>COPYRIGHT 2012 Public Library of Science</rights><rights>Barretti et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2012 Barretti et al 2012 Barretti et al</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c758t-c732b719a74c5ce8f5f95daa973b26781f9b78f3a96fe2af9e90472d50c906c53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/1326560788/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/1326560788?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,315,733,786,790,891,25783,27957,27958,37047,37048,44625,53827,53829,75483</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23077501$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Bacurau, Reury F. P.</contributor><creatorcontrib>Barretti, Diego Lopes Mendes</creatorcontrib><creatorcontrib>Magalhães, Flávio de Castro</creatorcontrib><creatorcontrib>Fernandes, Tiago</creatorcontrib><creatorcontrib>do Carmo, Everton Crivoi</creatorcontrib><creatorcontrib>Rosa, Kaleizu Teodoro</creatorcontrib><creatorcontrib>Irigoyen, Maria Claudia</creatorcontrib><creatorcontrib>Negrão, Carlos Eduardo</creatorcontrib><creatorcontrib>Oliveira, Edilamar Menezes</creatorcontrib><title>Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain</title><title>PloS one</title><addtitle>PLoS One</addtitle><description>Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain.
THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured.
The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p<0.05), while a tendency was found for OZR versus OZR+EXT (p = 0.07). In addition, exercise reduced (57%) triglycerides and (61%) LDL in the OZR+EXT. The systemic angiotensin I-converting enzyme (ACE) activity did not differ regardless of obesity and EXT, however, the OZR and OZR+EXT showed (66%) and (42%), respectively, less angiotensin II (Ang II) plasma concentration when compared with LZR. Furthermore, the results showed that EXT in the OZR prevented increase in CH, cardiac ACE activity, Ang II and AT2 receptor caused by obesity. In addition, exercise augmented cardiac ACE2 in both training groups.
Despite the unchanged ACE and lower systemic Ang II levels in obesity, the cardiac RAS was increased in OZR and EXT in obese Zucker rats reduced some of the cardiac RAS components and prevented obesity-related CH. These results show that EXT prevented the heart RAS hyperactivity and cardiac maladaptive morphological alterations in obese Zucker rats.</description><subject>ACE2</subject><subject>Aerobic exercises</subject><subject>Aerobics</subject><subject>Angiotensin</subject><subject>Angiotensin I</subject><subject>Angiotensin II</subject><subject>Angiotensin II - metabolism</subject><subject>Angiotensin-converting enzyme 2</subject><subject>Animals</subject><subject>Apoptosis</subject><subject>Biochemistry</subject><subject>Biology</subject><subject>Blood Pressure</subject><subject>Blotting, Western</subject><subject>Cardiomyopathy</subject><subject>Cardiovascular diseases</subject><subject>Cholesterol</subject><subject>Complications and side effects</subject><subject>Echocardiography</subject><subject>Enzymes</subject><subject>Exercise</subject><subject>Fitness training programs</subject><subject>Health aspects</subject><subject>Heart - physiopathology</subject><subject>Heart diseases</subject><subject>Heart Rate</subject><subject>High density lipoprotein</subject><subject>Hyperactivity</subject><subject>Hypertension</subject><subject>Hypertrophy</subject><subject>Laboratories</subject><subject>Lipoproteins (high density)</subject><subject>Lipoproteins (low density)</subject><subject>Low density lipoprotein</subject><subject>Male</subject><subject>Medical schools</subject><subject>Medicine</subject><subject>Molecular biology</subject><subject>Myosin Heavy Chains - metabolism</subject><subject>Obesity</subject><subject>Obesity - physiopathology</subject><subject>Peptidyl-dipeptidase A</subject><subject>Peptidyl-Dipeptidase A - metabolism</subject><subject>Physical Conditioning, Animal</subject><subject>Physical education</subject><subject>Physical fitness</subject><subject>Physical training</subject><subject>Physiological aspects</subject><subject>Rats</subject><subject>Rats, Zucker</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Renin</subject><subject>Renin-Angiotensin System</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>Risk factors</subject><subject>Rodents</subject><subject>Studies</subject><subject>Swimming</subject><subject>Training</subject><subject>Triglycerides</subject><subject>Weight control</subject><subject>Workloads</subject><issn>1932-6203</issn><issn>1932-6203</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNqNk01r3DAQhk1padK0_6C0gkJpD7uVLEuyLoUQ0nYhEOjXoRchy6Ndbb3SRrJL8u-rzTphXXIoBnkYP-8rzVhTFC8JnhMqyId1GKLX3XwbPMwxrjgh1aPimEhazniJ6eOD-Kh4ltIaY0Zrzp8WRyXFQjBMjgt7bi2YPqFgkYYYGmcQXEM0LgHqo3be-SUKHhkdW6cNipAzM-2XLvTgk_Mo3aQeNihH2qPQQBb-GsxviCjqHqVbk-fFE6u7BC_G90nx49P597Mvs4vLz4uz04uZEazu80rLRhCpRWWYgdoyK1mrtRS0KbmoiZWNqC3VklsotZUgcSXKlmEjMTeMnhSv977bLiQ1tigpQkvOOBZ1nYnFnmiDXqttdBsdb1TQTt0mQlwqHXtnOlBUNrTiVIOtTEWIaIQU2cVijYGWxmavj-NuQ7OB1oDPxXYT0-kX71ZqGf4oWgnM6jIbvBsNYrgaIPVq45KBrtMewpDPTQiVNWaEZ_TNP-jD1Y3UUucCnLch72t2puq0knXJJGc7av4AlZ8WNs7k-2Rdzk8E7yeCzPRw3S_1kJJafPv6_-zlzyn79oBdge76VQrd0Lvg0xSs9qCJIaUI9r7JBKvdONx1Q-3GQY3jkGWvDn_Qveju_tO_7qgFSQ</recordid><startdate>20121012</startdate><enddate>20121012</enddate><creator>Barretti, Diego Lopes Mendes</creator><creator>Magalhães, Flávio de Castro</creator><creator>Fernandes, Tiago</creator><creator>do Carmo, Everton Crivoi</creator><creator>Rosa, Kaleizu Teodoro</creator><creator>Irigoyen, Maria Claudia</creator><creator>Negrão, Carlos Eduardo</creator><creator>Oliveira, Edilamar Menezes</creator><general>Public Library of Science</general><general>Public Library of Science (PLoS)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IOV</scope><scope>ISR</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7QO</scope><scope>7RV</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TG</scope><scope>7TM</scope><scope>7U9</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB.</scope><scope>KB0</scope><scope>KL.</scope><scope>L6V</scope><scope>LK8</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>M7S</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PATMY</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PTHSS</scope><scope>PYCSY</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20121012</creationdate><title>Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain</title><author>Barretti, Diego Lopes Mendes ; Magalhães, Flávio de Castro ; Fernandes, Tiago ; do Carmo, Everton Crivoi ; Rosa, Kaleizu Teodoro ; Irigoyen, Maria Claudia ; Negrão, Carlos Eduardo ; Oliveira, Edilamar Menezes</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c758t-c732b719a74c5ce8f5f95daa973b26781f9b78f3a96fe2af9e90472d50c906c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>ACE2</topic><topic>Aerobic exercises</topic><topic>Aerobics</topic><topic>Angiotensin</topic><topic>Angiotensin I</topic><topic>Angiotensin II</topic><topic>Angiotensin II - metabolism</topic><topic>Angiotensin-converting enzyme 2</topic><topic>Animals</topic><topic>Apoptosis</topic><topic>Biochemistry</topic><topic>Biology</topic><topic>Blood Pressure</topic><topic>Blotting, Western</topic><topic>Cardiomyopathy</topic><topic>Cardiovascular diseases</topic><topic>Cholesterol</topic><topic>Complications and side effects</topic><topic>Echocardiography</topic><topic>Enzymes</topic><topic>Exercise</topic><topic>Fitness training programs</topic><topic>Health aspects</topic><topic>Heart - physiopathology</topic><topic>Heart diseases</topic><topic>Heart Rate</topic><topic>High density lipoprotein</topic><topic>Hyperactivity</topic><topic>Hypertension</topic><topic>Hypertrophy</topic><topic>Laboratories</topic><topic>Lipoproteins (high density)</topic><topic>Lipoproteins (low density)</topic><topic>Low density lipoprotein</topic><topic>Male</topic><topic>Medical schools</topic><topic>Medicine</topic><topic>Molecular biology</topic><topic>Myosin Heavy Chains - metabolism</topic><topic>Obesity</topic><topic>Obesity - 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>PloS one</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Barretti, Diego Lopes Mendes</au><au>Magalhães, Flávio de Castro</au><au>Fernandes, Tiago</au><au>do Carmo, Everton Crivoi</au><au>Rosa, Kaleizu Teodoro</au><au>Irigoyen, Maria Claudia</au><au>Negrão, Carlos Eduardo</au><au>Oliveira, Edilamar Menezes</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain</atitle><jtitle>PloS one</jtitle><addtitle>PLoS One</addtitle><date>2012-10-12</date><risdate>2012</risdate><volume>7</volume><issue>10</issue><spage>e46114</spage><epage>e46114</epage><pages>e46114-e46114</pages><issn>1932-6203</issn><eissn>1932-6203</eissn><notes>ObjectType-Article-1</notes><notes>SourceType-Scholarly Journals-1</notes><notes>ObjectType-Feature-2</notes><notes>content type line 23</notes><notes>Competing Interests: The authors have declared that no competing interests exist.</notes><notes>Conceived and designed the experiments: EMO CEN. Performed the experiments: DLMB FCM TF ECDC. Analyzed the data: DLMB EMO. Contributed reagents/materials/analysis tools: MCI KTR. Wrote the paper: DLMB EMO FCM.</notes><abstract>Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain.
THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured.
The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p<0.05), while a tendency was found for OZR versus OZR+EXT (p = 0.07). In addition, exercise reduced (57%) triglycerides and (61%) LDL in the OZR+EXT. The systemic angiotensin I-converting enzyme (ACE) activity did not differ regardless of obesity and EXT, however, the OZR and OZR+EXT showed (66%) and (42%), respectively, less angiotensin II (Ang II) plasma concentration when compared with LZR. Furthermore, the results showed that EXT in the OZR prevented increase in CH, cardiac ACE activity, Ang II and AT2 receptor caused by obesity. In addition, exercise augmented cardiac ACE2 in both training groups.
Despite the unchanged ACE and lower systemic Ang II levels in obesity, the cardiac RAS was increased in OZR and EXT in obese Zucker rats reduced some of the cardiac RAS components and prevented obesity-related CH. These results show that EXT prevented the heart RAS hyperactivity and cardiac maladaptive morphological alterations in obese Zucker rats.</abstract><cop>United States</cop><pub>Public Library of Science</pub><pmid>23077501</pmid><doi>10.1371/journal.pone.0046114</doi><tpages>e46114</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1932-6203 |
| ispartof | PloS one, 2012-10, Vol.7 (10), p.e46114-e46114 |
| issn | 1932-6203 1932-6203 |
| language | eng |
| recordid | cdi_plos_journals_1326560788 |
| source | Publicly Available Content Database; PubMed Central |
| subjects | ACE2 Aerobic exercises Aerobics Angiotensin Angiotensin I Angiotensin II Angiotensin II - metabolism Angiotensin-converting enzyme 2 Animals Apoptosis Biochemistry Biology Blood Pressure Blotting, Western Cardiomyopathy Cardiovascular diseases Cholesterol Complications and side effects Echocardiography Enzymes Exercise Fitness training programs Health aspects Heart - physiopathology Heart diseases Heart Rate High density lipoprotein Hyperactivity Hypertension Hypertrophy Laboratories Lipoproteins (high density) Lipoproteins (low density) Low density lipoprotein Male Medical schools Medicine Molecular biology Myosin Heavy Chains - metabolism Obesity Obesity - physiopathology Peptidyl-dipeptidase A Peptidyl-Dipeptidase A - metabolism Physical Conditioning, Animal Physical education Physical fitness Physical training Physiological aspects Rats Rats, Zucker Real-Time Polymerase Chain Reaction Renin Renin-Angiotensin System Reverse Transcriptase Polymerase Chain Reaction Risk factors Rodents Studies Swimming Training Triglycerides Weight control Workloads |
| title | Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain |
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