Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain

Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic...

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Bibliographic Details
Published in:PloS one 2012-10, Vol.7 (10), p.e46114-e46114
Main Authors: Barretti, Diego Lopes Mendes, Magalhães, Flávio de Castro, Fernandes, Tiago, do Carmo, Everton Crivoi, Rosa, Kaleizu Teodoro, Irigoyen, Maria Claudia, Negrão, Carlos Eduardo, Oliveira, Edilamar Menezes
Format: Article
Language:English
Subjects:
ACE2
Aerobic exercises
Aerobics
Angiotensin
Angiotensin I
Angiotensin II
Angiotensin II - metabolism
Angiotensin-converting enzyme 2
Animals
Apoptosis
Biochemistry
Biology
Blood Pressure
Blotting, Western
Cardiomyopathy
Cardiovascular diseases
Cholesterol
Complications and side effects
Echocardiography
Enzymes
Exercise
Fitness training programs
Health aspects
Heart - physiopathology
Heart diseases
Heart Rate
High density lipoprotein
Hyperactivity
Hypertension
Hypertrophy
Laboratories
Lipoproteins (high density)
Lipoproteins (low density)
Low density lipoprotein
Male
Medical schools
Medicine
Molecular biology
Myosin Heavy Chains - metabolism
Obesity
Obesity - physiopathology
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - metabolism
Physical Conditioning, Animal
Physical education
Physical fitness
Physical training
Physiological aspects
Rats
Rats, Zucker
Real-Time Polymerase Chain Reaction
Renin
Renin-Angiotensin System
Reverse Transcriptase Polymerase Chain Reaction
Risk factors
Rodents
Studies
Swimming
Training
Triglycerides
Weight control
Workloads
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Summary:Obesity and renin angiotensin system (RAS) hyperactivity are profoundly involved in cardiovascular diseases, however aerobic exercise training (EXT) can prevent obesity and cardiac RAS activation. The study hypothesis was to investigate whether obesity and its association with EXT alter the systemic and cardiac RAS components in an obese Zucker rat strain. THE RATS WERE DIVIDED INTO THE FOLLOWING GROUPS: Lean Zucker rats (LZR); lean Zucker rats plus EXT (LZR+EXT); obese Zucker rats (OZR) and obese Zucker rats plus EXT (OZR+EXT). EXT consisted of 10 weeks of 60-min swimming sessions, 5 days/week. At the end of the training protocol heart rate (HR), systolic blood pressure (SBP), cardiac hypertrophy (CH) and function, local and systemic components of RAS were evaluated. Also, systemic glucose, triglycerides, total cholesterol and its LDL and HDL fractions were measured. The resting HR decreased (∼12%) for both LZR+EXT and OZR+EXT. However, only the LZR+EXT reached significance (p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0046114