Involvement of the tubular ClC-type exchanger ClC-5 in glomeruli of human proteinuric nephropathies

Glomerular protein handling mechanisms have received much attention in studies of nephrotic syndrome. Histopathological findings in renal biopsies from severely proteinuric patients support the likelihood of protein endocytosis by podocytes. ClC-5 is involved in the endocytosis of albumin in the pro...

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Bibliographic Details

Published in:	PloS one 2012-09, Vol.7 (9), p.e45605-e45605
Main Authors:	Ceol, Monica, Tiralongo, Emilia, Baelde, Hans J, Vianello, Daniela, Betto, Giovanni, Marangelli, Annunziata, Bonfante, Luciana, Valente, Marialuisa, Della Barbera, Mila, D'Angelo, Angela, Anglani, Franca, Del Prete, Dorella
Format:	Article
Language:	eng
Subjects:	Albumin Biology Biopsy Care and treatment Chloride Channels - genetics Chloride Channels - metabolism Chloride Channels - physiology Development and progression Diabetes mellitus Diagnosis Endocytosis Feet Gene expression Genetic aspects Humans IgA nephropathy Immunoglobulin A Immunohistochemistry Kidney diseases Kidney Diseases - metabolism Kidney Glomerulus - metabolism Kidney transplantation Kidney Tubules - metabolism Kidneys Laboratories Lasers Localization Medicine Molecular biology Morphology mRNA Nephrectomy Nephrology Nephrotic syndrome Pathology Patients Physiological aspects Proteins Proteinuria Proteinuria - metabolism Real-Time Polymerase Chain Reaction RNA, Messenger - genetics Rodents
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