Triphala and its active constituent chebulinic acid are natural inhibitors of vascular endothelial growth factor-a mediated angiogenesis

Triphala churna (THL) is a combination of three fruits that has been used for many years in India for the treatment of various diseases. There are now reports which indicate that THL can inhibit growth of malignant tumors in animals. However, the mechanisms by which THL mediates its anti-tumor actio...

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Bibliographic Details

Published in:	PloS one 2012-08, Vol.7 (8), p.e43934
Main Authors:	Lu, Kai, Chakroborty, Debanjan, Sarkar, Chandrani, Lu, Tingting, Xie, Zhiliang, Liu, Zhongfa, Basu, Sujit
Format:	Article
Language:	eng
Subjects:	Acids Alzheimer's disease Alzheimers disease Angiogenesis Angiogenesis inhibitors Angiogenesis Inhibitors - pharmacology Angiogenesis Inhibitors - therapeutic use Animals Bioavailability Biology Cancer Cell Proliferation - drug effects Chemistry Cytotoxicity Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Human Umbilical Vein Endothelial Cells Humans Hydrolyzable Tannins - pharmacology Hydrolyzable Tannins - therapeutic use Male Medical treatment Medicine Mice Natural products Neovascularization, Pathologic - chemically induced Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - metabolism Pathogenesis Pathology Pharmaceutical sciences Pharmacy Phosphorylation Phosphorylation - drug effects Physiological aspects Plant Extracts - pharmacology Plant Extracts - therapeutic use Plasma Rodents Triphala Tumors Vascular endothelial growth factor Vascular Endothelial Growth Factor A - pharmacology Vascular Endothelial Growth Factor Receptor-2 - metabolism Vascular endothelial growth factor receptors
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