IL-6-174 G/C and -572 C/G polymorphisms and risk of Alzheimer's disease

Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches...

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Bibliographic Details
Published in:PloS one 2012-06, Vol.7 (6), p.e37858-e37858
Main Authors: Qi, Hui-Ping, Qu, Zheng-Yi, Duan, Shu-Rong, Wei, Shu-Qin, Wen, Shi-Rong, Bi, Sheng
Format: Article
Language:English
Subjects:
Advertising executives
Alzheimer Disease - genetics
Alzheimer's disease
Apolipoproteins
Biology
Confidence intervals
Cytokines
Dementia
Genes
Genetic aspects
Genetic Association Studies
Genetic Predisposition to Disease - genetics
Growth factors
Health risks
Humans
Inheritance Patterns - genetics
Interleukin 6
Interleukin-6 - genetics
Interleukins
Medical ethics
Medical research
Medicine
Meta-analysis
Neurodegenerative diseases
Neurology
Odds Ratio
Online searching
Polymorphism
Polymorphism, Single Nucleotide - genetics
Population
Risk
Risk factors
Studies
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Summary:Associations between interleukin 6 (IL-6) polymorphisms and Alzheimer's disease (AD) remain controversial and ambiguous. The aim of this meta-analysis is to explore more precise estimations for the relationship between IL-6-174 G/C and -572 C/G polymorphisms and risk for AD. Electronic searches for all publications in databases PubMed and EMBASE were conducted on the associations between IL-6 polymorphisms and risk for AD until January 2012. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated using fixed and random effects models. Twenty-seven studies were included with a total of 19,135 individuals, involving 6,632 AD patients and 12,503 controls. For IL-6-174 G/C polymorphism, the combined results showed significant differences in recessive model (CC vs. CG+GG: OR = 0.65, 95%CI = 0.52-0.82). As regards IL-6-572 C/G polymorphism, significant associations were shown in dominant model (CG+GG vs. CC: OR= 0.73, 95% CI = 0.62-0.86) and in additive model (GG vs. CC, OR= 0.66, 95% CI = 0.46-0.96). In conclusion, genotype CC of IL-6-174 G/C and genotype GG plus GC of IL-6-572 C/G could decrease the risk of AD.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0037858