Diabetes is the main factor accounting for hypomagnesemia in obese subjects

Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals. A) Case-control study: 200 obese subjects [50 with T2DM (case...

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Published in:PloS one 2012-01, Vol.7 (1), p.e30599
Main Authors: Lecube, Albert, Baena-Fustegueras, Juan Antonio, Fort, José Manuel, Pelegrí, Dolors, Hernández, Cristina, Simó, Rafael
Format: Article
Language:English
Subjects:
Adult
Analysis
Atherosclerosis
Bariatric surgery
Bariatric Surgery - statistics & numerical data
Biological variation
Biology
Body mass
Cardiovascular disease
Case-Control Studies
Control methods
Controlled Clinical Trials as Topic
Cross-Sectional Studies
Diabetes
Diabetes mellitus
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - complications
Diabetes Mellitus, Type 2 - epidemiology
Diabetes therapy
Diabetics
Endocrinology
Fasting
Female
Follow-Up Studies
Gastrointestinal surgery
Glucose
Glycosylated hemoglobin
Hemoglobin
Hospitals
Humans
Hypertension
Hypomagnesemia
Infrared radiation
Insulin resistance
Magnesium
Magnesium - blood
Magnesium deficiency
Magnesium Deficiency - blood
Magnesium Deficiency - epidemiology
Magnesium Deficiency - etiology
Male
Medicine
Metabolic syndrome
Middle Aged
Mortality
NMR
Nuclear magnetic resonance
Obesity
Obesity - blood
Obesity - complications
Obesity - epidemiology
Obesity - surgery
Oxidative stress
Patients
Regression analysis
Risk Factors
Studies
Surgery
Type 2 diabetes
Weight control
Weight Loss - physiology
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Summary:Type 2 diabetes (T2DM) and obesity are associated with magnesium deficiency. We aimed to determine whether the presence of type 2 diabetes and the degree of metabolic control are related to low serum magnesium levels in obese individuals. A) Case-control study: 200 obese subjects [50 with T2DM (cases) and 150 without diabetes (controls)] prospectively recruited. B) Interventional study: the effect of bariatric surgery on serum magnesium levels was examined in a subset of 120 obese subjects (40 with type 2 diabetes and 80 without diabetes). Type 2 diabetic patients showed lower serum magnesium levels [0.75±0.07 vs. 0.81±0.06 mmol/L; mean difference -0.06 (95% CI -0.09 to -0.04); p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0030599