Viral organization of human proteins

Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and...

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Bibliographic Details
Published in:PloS one 2010-08, Vol.5 (8), p.e11796-e11796
Main Authors: Wuchty, Stefan, Siwo, Geoffrey, Ferdig, Michael T
Format: Article
Language:English
Subjects:
Acids
Biology
Clubs
Computational Biology/Signaling Networks
Computational Biology/Systems Biology
Development and progression
DNA binding proteins
Drug development
Drugs
Entanglement
Health aspects
HIV
HIV infections
HIV-1 - metabolism
HIV-1 - physiology
Host-Pathogen Interactions
Human immunodeficiency virus
Human immunodeficiency virus 1
Human Immunodeficiency Virus Proteins - metabolism
Humans
Infections
Infectious Diseases/Viral Infections
Kinases
Oligarchy
Pathogenesis
Pathogens
Phosphorylation
Protein Binding
Protein interaction
Protein kinase
Protein kinases
Protein Kinases - metabolism
Proteins
Systems Biology
Topology
Transcription factors
Transcription Factors - metabolism
Viral infections
Viral proteins
Viruses
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Summary:Although maps of intracellular interactions are increasingly well characterized, little is known about large-scale maps of host-pathogen protein interactions. The investigation of host-pathogen interactions can reveal features of pathogenesis and provide a foundation for the development of drugs and disease prevention strategies. A compilation of experimentally verified interactions between HIV-1 and human proteins and a set of HIV-dependency factors (HDF) allowed insights into the topology and intricate interplay between viral and host proteins on a large scale. We found that targeted and HDF proteins appear predominantly in rich-clubs, groups of human proteins that are strongly intertwined among each other. These assemblies of proteins may serve as an infection gateway, allowing the virus to take control of the human host by reaching protein pathways and diversified cellular functions in a pronounced and focused way. Particular transcription factors and protein kinases facilitate indirect interactions between HDFs and viral proteins. Discerning the entanglement of directly targeted and indirectly interacting proteins may uncover molecular and functional sites that can provide novel perspectives on the progression of HIV infection and highlight new avenues to fight this virus.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0011796