abd-A regulation by the iab-8 noncoding RNA

The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repressi...

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Bibliographic Details
Published in:PLoS genetics 2012-05, Vol.8 (5), p.e1002720-e1002720
Main Authors: Gummalla, Maheshwar, Maeda, Robert K, Castro Alvarez, Javier J, Gyurkovics, Henrik, Singari, Swetha, Edwards, Kevin A, Karch, François, Bender, Welcome
Format: Article
Language:English
Subjects:
Abdomen
Abdomen - growth & development
Animals
Antisense RNA
Base Sequence
Biology
Drosophila - genetics
Drosophila - growth & development
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Embryonic Development - genetics
Embryos
Gene Expression Regulation, Developmental
Genes
Genetic aspects
Genetic transcription
Genetics
Genomes
Grants
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Infertility - genetics
Medical research
MicroRNAs - genetics
MicroRNAs - metabolism
Molecular Sequence Data
Morphogenesis - genetics
Mutation
Neurons - cytology
Neurons - metabolism
Nuclear Proteins - genetics
Nuclear Proteins - metabolism
Physiological aspects
Promoter Regions, Genetic
Proteins
Regulation
RNA polymerase
RNA, Untranslated - genetics
Transcription factors
Transcription Factors - genetics
Transcription Factors - metabolism
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Summary:The homeotic genes in Drosophila melanogaster are aligned on the chromosome in the order of the body segments that they affect. The genes affecting the more posterior segments repress the more anterior genes. This posterior dominance rule must be qualified in the case of abdominal-A (abd-A) repression by Abdominal-B (Abd-B). Animals lacking Abd-B show ectopic expression of abd-A in the epidermis of the eighth abdominal segment, but not in the central nervous system. Repression in these neuronal cells is accomplished by a 92 kb noncoding RNA. This "iab-8 RNA" produces a micro RNA to repress abd-A, but also has a second, redundant repression mechanism that acts only "in cis." Transcriptional interference with the abd-A promoter is the most likely mechanism.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1002720