Four novel Loci (19q13, 6q24, 12q24, and 5q14) influence the microcirculation in vivo

There is increasing evidence that the microcirculation plays an important role in the pathogenesis of cardiovascular diseases. Changes in retinal vascular caliber reflect early microvascular disease and predict incident cardiovascular events. We performed a genome-wide association study to identify...

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Published in:	PLoS genetics 2010-10, Vol.6 (10), p.e1001184-e1001184
Main Authors:	Ikram, M Kamran, Sim, Xueling, Xueling, Sim, Jensen, Richard A, Cotch, Mary Frances, Hewitt, Alex W, Ikram, M Arfan, Wang, Jie Jin, Klein, Ronald, Klein, Barbara E K, Breteler, Monique M B, Cheung, Ning, Liew, Gerald, Mitchell, Paul, Uitterlinden, Andre G, Rivadeneira, Fernando, Hofman, Albert, de Jong, Paulus T V M, van Duijn, Cornelia M, Kao, Linda, Cheng, Ching-Yu, Smith, Albert Vernon, Glazer, Nicole L, Lumley, Thomas, McKnight, Barbara, Psaty, Bruce M, Jonasson, Fridbert, Eiriksdottir, Gudny, Aspelund, Thor, Harris, Tamara B, Launer, Lenore J, Taylor, Kent D, Li, Xiaohui, Iyengar, Sudha K, Xi, Quansheng, Sivakumaran, Theru A, Mackey, David A, Macgregor, Stuart, Martin, Nicholas G, Young, Terri L, Bis, Josh C, Wiggins, Kerri L, Heckbert, Susan R, Hammond, Christopher J, Andrew, Toby, Fahy, Samantha, Attia, John, Holliday, Elizabeth G, Scott, Rodney J, Islam, F M Amirul, Rotter, Jerome I, McAuley, Annie K, Boerwinkle, Eric, Tai, E Shyong, Gudnason, Vilmundur, Siscovick, David S, Vingerling, Johannes R, Wong, Tien Y
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Aged Aged, 80 and over Cardiovascular disease Cardiovascular Diseases - genetics Cardiovascular Diseases - physiopathology Cardiovascular Disorders/Vascular Biology Child Child, Preschool Chromosomes, Human, Pair 12 Chromosomes, Human, Pair 19 Chromosomes, Human, Pair 5 Chromosomes, Human, Pair 6 Cohort Studies Epidemiology Female Genetic Loci - genetics Genetics and Genomics/Population Genetics Genome-Wide Association Study - methods Hospitals Humans Male Medical research Meta-Analysis as Topic Microcirculation Middle Aged Ophthalmology/Retinal Disorders Polymorphism, Single Nucleotide Retinal Vessels - physiopathology Whites - genetics Young Adult
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