Y chromosome lineage- and village-specific genes on chromosomes 1p22 and 6q27 control visceral leishmaniasis in Sudan

Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan usin...

Full description

Saved in:
Bibliographic Details
Published in:PLoS genetics 2007-05, Vol.3 (5), p.e71-e71
Main Authors: Miller, E Nancy, Fadl, Manal, Mohamed, Hiba S, Elzein, Abier, Jamieson, Sarra E, Cordell, Heather J, Peacock, Christopher S, Fakiola, Michaela, Raju, Madhuri, Khalil, Eltahir A, Elhassan, Ahmed, Musa, Ahmed M, Ibrahim, Muntaser E, Blackwell, Jenefer M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alleles
Child
Child, Preschool
Chromosome Mapping
Chromosomes
Chromosomes, Human, Pair 1 - genetics
Chromosomes, Human, Pair 6 - genetics
Chromosomes, Human, Y - genetics
Consanguinity
Control
DNA, Mitochondrial - genetics
Female
Genes
Genetic aspects
Genetics
Genetics and Genomics
Genome, Human - genetics
Genomics
Haplotypes
Health aspects
Homo (Human)
Humans
Kala-azar
Leishmaniasis, Visceral - genetics
Lod Score
Male
Microsatellite Repeats - genetics
Molecular Sequence Data
Parasitic diseases
Pedigree
Rural Health
Rural Population
Social aspects
Species Specificity
Sudan
Y chromosome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Familial clustering and ethnic differences suggest that visceral leishmaniasis caused by Leishmania donovani is under genetic control. A recent genome scan provided evidence for a major susceptibility gene on Chromosome 22q12 in the Aringa ethnic group in Sudan. We now report a genome-wide scan using 69 families with 173 affected relatives from two villages occupied by the related Masalit ethnic group. A primary ten-centimorgan scan followed by refined mapping provided evidence for major loci at 1p22 (LOD score 5.65; nominal p = 1.72 x 10(-7); empirical p < 1 x 10(-5); lambdaS = 5.1) and 6q27 (LOD score 3.74; nominal p = 1.68 x 10(-5); empirical p < 1 x 10(-4); lambdaS = 2.3) that were Y chromosome-lineage and village-specific. Neither village supported a visceral leishmaniasis susceptibility gene on 22q12. The results suggest strong lineage-specific genes due to founder effect and consanguinity in these recently immigrant populations. These chance events in ethnically uniform African populations provide a powerful resource in the search for genes and mechanisms that regulate this complex disease.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.0030071