Evidence for more than one Parkinson's disease-associated variant within the HLA region

Parkinson's disease (PD) was recently found to be associated with HLA in a genome-wide association study (GWAS). Follow-up GWAS's replicated the PD-HLA association but their top hits differ. Do the different hits tag the same locus or is there more than one PD-associated variant within HLA...

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Bibliographic Details
Published in:PloS one 2011-11, Vol.6 (11), p.e27109-e27109
Main Authors: Hill-Burns, Erin M, Factor, Stewart A, Zabetian, Cyrus P, Thomson, Glenys, Payami, Haydeh
Format: Article
Language:English
Subjects:
Alleles
Analysis
Antigens
Biology
Conditioning
Consortia
DQA2 gene
Epidemiology
Gene expression
Genetic aspects
Genetic Predisposition to Disease - genetics
Genome-wide association studies
Genome-Wide Association Study - methods
Genomes
Genomics
Genotype
Haplotypes
Histocompatibility antigen HLA
HLA antigens
HLA-DQ Antigens - genetics
HLA-DR alpha-Chains - genetics
HLA-DR5 Antigen - genetics
Humans
Inflammation
Influenza
Loci
Medicine
Movement disorders
Neurodegenerative diseases
Parkinson Disease - genetics
Parkinson's disease
Polymorphism, Single Nucleotide - genetics
Risk
Single-nucleotide polymorphism
Studies
Citations: Items that cite this one
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Summary:Parkinson's disease (PD) was recently found to be associated with HLA in a genome-wide association study (GWAS). Follow-up GWAS's replicated the PD-HLA association but their top hits differ. Do the different hits tag the same locus or is there more than one PD-associated variant within HLA? We show that the top GWAS hits are not correlated with each other (0.00≤r(2)≤0.15). Using our GWAS (2000 cases, 1986 controls) we conducted step-wise conditional analysis on 107 SNPs with P
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0027109