Reduced food intake and body weight in mice deficient for the G protein-coupled receptor GPR82

G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic loci with signatures of recent selection in humans contain GPCR...

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Bibliographic Details
Published in:PloS one 2011-12, Vol.6 (12), p.e29400-e29400
Main Authors: Engel, Kathrin M Y, Schröck, Kristin, Teupser, Daniel, Holdt, Lesca Miriam, Tönjes, Anke, Kern, Matthias, Dietrich, Kerstin, Kovacs, Peter, Krügel, Ute, Scheidt, Holger A, Schiller, Jürgen, Huster, Daniel, Brockmann, Gudrun A, Augustin, Martin, Thiery, Joachim, Blüher, Matthias, Stumvoll, Michael, Schöneberg, Torsten, Schulz, Angela
Format: Article
Language:English
Subjects:
Abnormalities
Animals
Biochemistry
Bioinformatics
Biology
Biophysics
Body fat
Body Weight
Deoxyribonucleic acid
Diet
DNA
Feeding Behavior
Food
Food intake
G protein-coupled receptors
G proteins
Genetic diversity
Genomes
Genotype
Genotype & phenotype
Glucose
Glucose tolerance
Glucose Tolerance Test
Haplotypes
Health physics
House mouse
Human evolution
Humans
Hypotheses
Insulin
Internal medicine
Kinases
Laboratories
Lipids
Mass spectrometry
Medicine
Membrane proteins
Mice
Mice, Knockout
Mutagenesis
Mutation
Phenotype
Physics
Physiological aspects
Physiology
Proteins
Receptors
Receptors, G-Protein-Coupled - genetics
Receptors, G-Protein-Coupled - physiology
Rodents
Studies
Transgenic animals
Triglycerides - blood
Weight reduction
X Chromosome
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Summary:G protein-coupled receptors (GPCR) are involved in the regulation of numerous physiological functions. Therefore, GPCR variants may have conferred important selective advantages during periods of human evolution. Indeed, several genomic loci with signatures of recent selection in humans contain GPCR genes among them the X-chromosomally located gene for GPR82. This gene encodes a so-called orphan GPCR with unknown function. To address the functional relevance of GPR82 gene-deficient mice were characterized. GPR82-deficient mice were viable, reproduced normally, and showed no gross anatomical abnormalities. However, GPR82-deficient mice have a reduced body weight and body fat content associated with a lower food intake. Moreover, GPR82-deficient mice showed decreased serum triacylglyceride levels, increased insulin sensitivity and glucose tolerance, most pronounced under Western diet. Because there were no differences in respiratory and metabolic rates between wild-type and GPR82-deficient mice our data suggest that GPR82 function influences food intake and, therefore, energy and body weight balance. GPR82 may represent a thrifty gene most probably representing an advantage during human expansion into new environments.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0029400