The role of the novel exopolyphosphatase MT0516 in Mycobacterium tuberculosis drug tolerance and persistence

Inorganic polyphosphate (poly P) has been postulated to play a regulatory role in the transition to bacterial persistence. In bacteria, poly P balance in the cell is maintained by the hydrolysis activity of the exopolyphosphatase PPX. However, the Mycobacterium tuberculosis PPX has not been characte...

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Bibliographic Details

Published in:	PloS one 2011-11, Vol.6 (11), p.e28076-e28076
Main Authors:	Thayil, Seema M, Morrison, Norman, Schechter, Norman, Rubin, Harvey, Karakousis, Petros C
Format:	Article
Language:	eng
Subjects:	Acid Anhydride Hydrolases - deficiency Acid Anhydride Hydrolases - metabolism Adaptation Animals Anti-Bacterial Agents - pharmacology Antibiotics Antitubercular agents Bacteria Bacterial Proteins - metabolism Biology Cell survival Cell walls Deceleration Deficient mutant DNA Transposable Elements - genetics Drug resistance Drug Resistance, Bacterial - drug effects Drug therapy Drug tolerance E coli Escherichia coli Exopolyphosphatase Female Gene expression Genes Genetic Complementation Test Genomes Guinea Pigs Humans Hydrolysis Hydrolysis - drug effects Infections Intracellular levels Isoniazid Isoniazid - pharmacology Kinases Lesions Lung - drug effects Lung - microbiology Lung - pathology Lungs Macrophages Medicine Models, Molecular Mutation - genetics Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - enzymology Mycobacterium tuberculosis - growth & development Mycobacterium tuberculosis - pathogenicity Neisseria meningitidis Polypeptides Polyphosphates - metabolism Proteins Recombination, Genetic - genetics Signaling Silicon compounds Silicon germanides Structural Homology, Protein Survival Tuberculosis Virulence - drug effects
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