The heritability of amyotrophic lateral sclerosis in a clinically ascertained United States research registry

The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another...

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Bibliographic Details
Published in:PloS one 2011-11, Vol.6 (11), p.e27985-e27985
Main Authors: Wingo, Thomas S, Cutler, David J, Yarab, Nicole, Kelly, Crystal M, Glass, Jonathan D
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Amyotrophic Lateral Sclerosis - epidemiology
Amyotrophic Lateral Sclerosis - genetics
Biology
Biomedical Research - statistics & numerical data
Chromosomes
Confidence intervals
Demography
Development and progression
Disease
Epidemiology
Estimates
Families & family life
Family medical history
Female
Genetic aspects
Genetic factors
Genetics
Heredity
Heritability
Humans
Inheritance Patterns - genetics
Inner city
Liability
Lubricants
Male
Medical research
Medicine
Middle Aged
Mutation
Neurology
Offspring
Parents
Parents & parenting
Population
Progeny
Registries - statistics & numerical data
Studies
Superoxide dismutase
Superoxides
Twins
United States - epidemiology
Zinc
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Summary:The genetic basis of amyotrophic lateral sclerosis (ALS) is not entirely clear. While there are families with rare highly penetrant mutations in Cu/Zn superoxide dismutase 1 and several other genes that cause apparent Mendelian inheritance of the disease, most ALS occurs in families without another affected individual. However, twin studies suggest that all ALS has a substantial genetic basis. Herein, we estimate the genetic contribution to ALS in a clinically ascertained case series from the United States. We used the database of the Emory ALS Center to ascertain individuals with ALS along with their family histories to determine the concordance among parents and offspring for the disease. We found that concordance for all parent-offspring pairs was low (
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0027985