Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene

In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was seque...

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Bibliographic Details
Published in:	PloS one 2011-09, Vol.6 (9), p.e24491-e24491
Main Authors:	Liu, Elizabeth B, Ferreyra, Leonardo, Fischer, Stephen L, Pavan, Jorge V, Nates, Silvia V, Hudson, Nolan Ryan, Tirado, Damaris, Dyer, David W, Chodosh, James, Seto, Donald, Jones, Morris S
Format:	Article
Language:	eng
Subjects:	Acquired immune deficiency syndrome Adenovirus Adenoviruses Adenoviruses, Human - classification Adenoviruses, Human - genetics AIDS Analysis Apoptosis Bioinformatics Biology Capsid Proteins - genetics Computational Biology Diarrhea Dietary fiber Feces Fibers Genes Genetic analysis Genetic aspects Genome, Viral - genetics Genomes Genomics Hexons Human adenovirus Humans Immunology Laboratories Ligands Neutralization Pathogens Phylogenetics Phylogeny Proteins Public health Recombinant Proteins - genetics Recombination Virology Viruses
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Summary:	In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.
ISSN:	1932-6203 1932-6203