Anticancer activities of six selected natural compounds of some Cameroonian medicinal plants

Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-ger...

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Bibliographic Details
Published in:PloS one 2011-08, Vol.6 (8), p.e21762-e21762
Main Authors: Kuete, Victor, Wabo, Hippolyte K, Eyong, Kenneth O, Feussi, Michel T, Wiench, Benjamin, Krusche, Benjamin, Tane, Pierre, Folefoc, Gabriel N, Efferth, Thomas
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Anticancer properties
Antineoplastic agents
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Apoptosis
Biochemistry
Biological Products - chemistry
Biological Products - pharmacology
Biology
Biotechnology
Breast cancer
Cameroon
Cancer
Cancer therapies
Cancer treatment
Capillaries
Capillaries - drug effects
Capillaries - growth & development
Caspase
Caspase 3 - metabolism
Caspase 7 - metabolism
Caspase-3
Cell cycle
Cell Cycle - drug effects
Cell Death - drug effects
Cell growth
Cell Line, Tumor
Cell Proliferation - drug effects
Cervix
Chemistry
Chorioallantoic membrane
Cytotoxicity
Doxorubicin - pharmacology
Eggs
Herbal medicine
Humans
Leukemia
Medicinal plants
Medicine
Melanoma
Microbial drug resistance
Mode of action
Multidrug resistance
Natural products
Newbouldia laevis
Oils & fats
Organic chemistry
Pancreas
Pharmaceuticals
Pharmacy
Plants, Medicinal - chemistry
Quail
Science
Toxicity
Tumor cell lines
Vismia laurentii
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Summary:Natural products are well recognized as sources of drugs in several human ailments. In the present work, we carried out a preliminary screening of six natural compounds, xanthone V(1) (1); 2-acetylfuro-1,4-naphthoquinone (2); physcion (3); bisvismiaquinone (4); vismiaquinone (5); 1,8-dihydroxy-3-geranyloxy-6-methylanthraquinone (6) against MiaPaCa-2 pancreatic and CCRF-CEM leukemia cells and their multidrug-resistant subline, CEM/ADR5000. Compounds 1 and 2 were then tested in several other cancer cells and their possible mode of action were investigated. The tested compounds were previously isolated from the Cameroonian medicinal plants Vismia laurentii (1, 3, 4, 5 and 6) and Newbouldia laevis (2). The preliminary cytotoxicity results allowed the selection of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, which were then tested on a panel of cancer cell lines. The study was also extended to the analysis of cell cycle distribution, apoptosis induction, caspase 3/7 activation and the anti-angiogenic properties of xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone. IC(50) values around or below 4 µg/ml were obtained on 64.29% and 78.57% of the tested cancer cell lines for xanthone V(1) and 2-acetylfuro-1,4-naphthoquinone, respectively. The most sensitive cell lines (IC(50)
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0021762