Circulating strains of human respiratory syncytial virus in central and south America

Human respiratory syncytial virus (HRSV) is a major cause of viral lower respiratory tract infections among infants and young children. HRSV strains vary genetically and antigenically and have been classified into two broad subgroups, A and B (HRSV-A and HRSV-B, respectively). To date, little is kno...

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Bibliographic Details
Published in:PloS one 2011-08, Vol.6 (8), p.e22111-e22111
Main Authors: Sovero, Merly, Garcia, Josefina, Kochel, Tadeusz, Laguna-Torres, V Alberto, Gomez, Jorge, Chicaiza, Wilson, Barrantes, Melvin, Sanchez, Felix, Jimenez, Mirna, Comach, Guillermo, de Rivera, Ivette Lorenzana, Arango, Ana E, Agudo, Roberto, Halsey, Eric S
Format: Article
Language:English
Subjects:
Animals
Antigens
Base Sequence
Biodiversity
Biology
Cell Line
Central America
Children
DNA Primers
Epidemiology
G proteins
Gene sequencing
Genetic diversity
Genotypes
Humans
Infants
Infection
Medicine
Phylogeny
Respiratory syncytial virus
Respiratory Syncytial Viruses - chemistry
Respiratory Syncytial Viruses - isolation & purification
Respiratory therapy
Respiratory tract
Respiratory tract diseases
Reverse Transcriptase Polymerase Chain Reaction
South America
Strains (organisms)
Subgroups
Variable region
Viruses
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Summary:Human respiratory syncytial virus (HRSV) is a major cause of viral lower respiratory tract infections among infants and young children. HRSV strains vary genetically and antigenically and have been classified into two broad subgroups, A and B (HRSV-A and HRSV-B, respectively). To date, little is known about the circulating strains of HRSV in Latin America. We have evaluated the genetic diversity of 96 HRSV strains by sequencing a variable region of the G protein gene of isolates collected from 2007 to 2009 in Central and South America. Our results show the presence of the two antigenic subgroups of HRSV during this period with the majority belonging to the genotype HRSV-A2.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0022111