Human Serum Metabolome

Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically i...

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Bibliographic Details
Published in:PloS one 2011-02, Vol.6 (2), p.e16957-e16957
Main Authors: Psychogios, Nikolaos, Hau, David D, Peng, Jun, Guo, An Chi, Mandal, Rupasri, Bouatra, Souhaila, Sinelnikov, Igor, Krishnamurthy, Ramanarayan, Eisner, Roman, Gautam, Bijaya, Young, Nelson, Xia, Jianguo, Knox, Craig, Dong, Edison, Huang, Paul, Hollander, Zsuzsanna, Pedersen, Theresa L, Smith, Steven R, Bamforth, Fiona, Greiner, Russ, McManus, Bruce, Newman, John W, Goodfriend, Theodore, Wishart, David S, Flower, Darren
Format: Article
Language:English
Subjects:
Adult
Aged
Agriculture
Biology
Blood
Blood Chemical Analysis - methods
Blood Proteins - analysis
Blood Proteins - metabolism
blood serum
Case-Control Studies
Cerebrospinal fluid
Chemistry
Chromatography
Databases, Protein
Fatty acids
Female
Fluids
Gas Chromatography-Mass Spectrometry
Health
Humans
Identification methods
Ions
Labeling
Lipids
Lipids - analysis
Lipids - blood
Male
Mass spectrometry
Medicine
Metabolism
Metabolites
metabolome
Metabolome - physiology
Metabolomics
Metabolomics - methods
Middle Aged
NMR
Nuclear magnetic resonance
nuclear magnetic resonance spectroscopy
Nuclear Magnetic Resonance, Biomolecular
Nutrition research
Osmolar Concentration
Platforms
Review Literature as Topic
Science
Scientific imaging
Serum - chemistry
Serum - metabolism
Spectrometry, Mass, Electrospray Ionization
Technology
Technology assessment
Urine
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Description
Summary:Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the metabolomics community to develop centralized metabolite reference resources for certain clinically important biofluids, such as cerebrospinal fluid, urine and blood. As part of an ongoing effort to systematically characterize the human metabolome through the Human Metabolome Project, we have undertaken the task of characterizing the human serum metabolome. In doing so, we have combined targeted and non-targeted NMR, GC-MS and LC-MS methods with computer-aided literature mining to identify and quantify a comprehensive, if not absolutely complete, set of metabolites commonly detected and quantified (with today's technology) in the human serum metabolome. Our use of multiple metabolomics platforms and technologies allowed us to substantially enhance the level of metabolome coverage while critically assessing the relative strengths and weaknesses of these platforms or technologies. Tables containing the complete set of 4229 confirmed and highly probable human serum compounds, their concentrations, related literature references and links to their known disease associations are freely available at http://www.serummetabolome.ca .
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0016957