Characterization of Dengue virus type 2: new insights on the 2010 Brazilian epidemic

Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic...

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Bibliographic Details
Published in:PloS one 2010-07, Vol.5 (7), p.e11811-e11811
Main Authors: Romano, Camila Malta, de Matos, Andréia Manso, Araújo, Evaldo Stanislau A, Villas-Boas, Lucy Santos, da Silva, Wanessa Cardoso, Oliveira, Olímpia M N P F, Carvalho, Karina I, de Souza, Ana Carolina Mamana, Rodrigues, Celia L, Levi, José Eduardo, Kallas, Esper G, Pannuti, Claudio Sergio
Format: Article
Language:English
Subjects:
Analysis
Brazil - epidemiology
Cladistic analysis
Clustering
Dengue
Dengue - epidemiology
Dengue - virology
Dengue fever
Dengue virus
Dengue Virus - classification
Dengue Virus - genetics
Dengue Virus - physiology
Dengue virus type 2
Disease Outbreaks - statistics & numerical data
Epidemics
Fever
Genotype & phenotype
Genotypes
Humans
Infections
Infectious Diseases/Epidemiology and Control of Infectious Diseases
Infectious Diseases/Neglected Tropical Diseases
Outbreaks
Phylogeny
Public Health and Epidemiology/Epidemiology
Public Health and Epidemiology/Health Policy
Public Health and Epidemiology/Infectious Diseases
Reverse Transcriptase Polymerase Chain Reaction
Serotypes
Vector-borne diseases
Viral diseases
Viruses
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Summary:Dengue viruses (DENV) serotypes 1, 2, and 3 have been causing yearly outbreaks in Brazil. In this study, we report the re-introduction of DENV2 in the coast of São Paulo State. Partial envelope viral genes were sequenced from eighteen patients with dengue fever during the 2010 epidemic. Phylogenetic analysis showed this strain belongs to the American/Asian genotype and was closely related to the virus that circulated in Rio de Janeiro in 2007 and 2008. The phylogeny also showed no clustering by clinical presentation, suggesting that the disease severity could not be explained by distinct variants or genotypes. The time of the most recent common ancestor of American/Asian genotype and the São Paulo and Rio de Janeiro (SP/RJ) monophyletic cluster was estimated to be around 40 and 10 years, respectively. Since this virus was first identified in Brazil in 2007, we suggest that it was already circulating in the country before causing the first documented outbreak. This is the first description of the 2010 outbreak in the State of São Paulo, Brazil, and should contribute to efforts to control and monitor the spread of DENVs in endemic areas.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0011811