Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni

Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid m...

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Bibliographic Details
Published in:PLoS neglected tropical diseases 2012-02, Vol.6 (2), p.e1474
Main Authors: Portela, Julien, Boissier, Jérôme, Gourbal, Benjamin, Pradines, Vincent, Collière, Vincent, Coslédan, Frédéric, Meunier, Bernard, Robert, Anne
Format: Article
Language:English
Subjects:
Aminoquinolines - administration & dosage
Aminoquinolines - pharmacology
Animals
Anthelmintics - administration & dosage
Anthelmintics - pharmacology
Antimalarials
Biodiversity and Ecology
Biology
Disease
Dosage and administration
Drug Synergism
Drug therapy
Environmental Sciences
Female
Humans
Larva - drug effects
Malaria
Male
Medicine
Mice
Microscopy
Parasites
Praziquantel - administration & dosage
Praziquantel - pharmacology
Schistosoma mansoni - drug effects
Schistosomiasis
Schistosomiasis mansoni - drug therapy
Treatment Outcome
Tropical diseases
Worms
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Summary:Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action, not only the alkylation of heme. The synergy observed with praziquantel on infected mice is in favor of the development of these trioxaquines as potential anti-schistosomal agents.
ISSN:1935-2735
1935-2727
1935-2735
DOI:10.1371/journal.pntd.0001474