Risk for asthma in offspring of asthmatic mothers versus fathers: a meta-analysis

Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspring than does paternal disease. However, a handful have shown the opposite. Given this disparity, a meta-analysis is necessary to determine the veracity and magnitude of the "maternal effec...

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Bibliographic Details
Published in:PloS one 2010-04, Vol.5 (4), p.e10134
Main Authors: Lim, Robert H, Kobzik, Lester, Dahl, Morten
Format: Article
Language:English
Subjects:
Age Factors
Asthma
Asthma - epidemiology
Asthma - genetics
Breastfeeding & lactation
Child
Childhood asthma
Children
Comparative analysis
Confidence intervals
Cultural differences
Dermatitis
Disease Susceptibility
Environmental health
Epidemiology
Ethnicity
Family Health
Fathers
Female
Health risks
Health screening
Hospitals
Humans
Inheritance Patterns
Male
Medical ethics
Medical research
Meta-analysis
Mothers
Odds Ratio
Offspring
Pediatrics and Child Health/Respiratory Pediatrics
Pregnancy
Public health
Public Health and Epidemiology/Epidemiology
Quality
Respiratory Medicine/Asthma
Risk
Risk assessment
Risk factors
Socioeconomic factors
Studies
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Summary:Many human epidemiologic studies demonstrate that maternal asthma confers greater risk of asthma to offspring than does paternal disease. However, a handful have shown the opposite. Given this disparity, a meta-analysis is necessary to determine the veracity and magnitude of the "maternal effect." We screened the medical literature from 1966 to 2009 and performed a meta-analysis to compare the effect of maternal asthma vs. paternal asthma on offspring asthma susceptibility. Aggregating data from 33 studies, the odds ratio for asthma in children of asthmatic mothers compared with non-asthmatic mothers was significantly increased at 3.04 (95% confidence interval: 2.59-3.56). The corresponding odds ratio for asthma in children of asthmatic fathers was increased at 2.44 (2.14-2.79). When comparing the odds ratios, maternal asthma conferred greater risk of disease than did paternal asthma (3.04 vs. 2.44, p = 0.037). When analyzing the studies in which asthma was diagnosed by a physician the odds ratios were attenuated and no significant differences were observed (2.85 vs. 2.48, N = 18, p = 0.37). Similarly, no significant differences were observed between maternal and paternal odds ratios when analyzing the studies in which the patient population was 5 years or older (3.15 vs. 2.60, p = 0.14). However, in all cases the trend remained the same, that maternal asthma was a greater risk factor for asthma than paternal. The results show that maternal asthma increases offspring disease risk to a greater extent than paternal disease.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0010134