Culture-modified bone marrow cells attenuate cardiac and renal injury in a chronic kidney disease rat model via a novel antifibrotic mechanism

Most forms of chronic kidney disease are characterized by progressive renal and cardiac fibrosis leading to dysfunction. Preliminary evidence suggests that various bone marrow-derived cell populations have antifibrotic effects. In exploring the therapeutic potential of bone marrow derived cells in c...

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Bibliographic Details

Published in:	PloS one 2010-03, Vol.5 (3), p.e9543-e9543
Main Authors:	Yuen, Darren A, Connelly, Kim A, Advani, Andrew, Liao, Christine, Kuliszewski, Michael A, Trogadis, Judy, Thai, Kerri, Advani, Suzanne L, Zhang, Yuan, Kelly, Darren J, Leong-Poi, Howard, Keating, Armand, Marsden, Philip A, Stewart, Duncan J, Gilbert, Richard E
Format:	Article
Language:	eng
Subjects:	Animals B cells Blood pressure Bone marrow Bone Marrow Cells - cytology Bone Marrow Cells - pathology Cardiovascular Disorders/Heart Failure Cell culture Chronic kidney failure Collagen Collagen (type IV) Collagen - chemistry Conditioning Creatinine Creatinine - blood Culture Media, Conditioned - pharmacology Diabetes Diastolic pressure Disease Models, Animal Disease Progression Excretion Fibroblasts Fibrosis Fibrosis - pathology Glomerulonephritis - pathology Growth factors Health aspects Heart Heart diseases Heart failure Heart Injuries - pathology In vitro methods and tests Kidney - injuries Kidney - metabolism Kidney diseases Kidney Failure, Chronic - pathology Kinases Knowledge Liver Localization Male Medicine Mercury Nephrectomy Nephrology/Chronic Kidney Disease Nephrology/Renal Physiology Nitric oxide Phosphorylation Pulmonary hypertension Rats Rats, Inbred F344 Rodents Secretion Signaling Spleen Stiffness Stromal cells Stromal Cells - cytology Structure-function relationships Syngeneic grafts Transforming growth factor Transforming Growth Factor beta - metabolism Ventricle
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