Increased alpha-defensins 1-3 production by dendritic cells in HIV-infected individuals is associated with slower disease progression

Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce alpha-defensins1-3 and that alpha-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction play...

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Bibliographic Details
Published in:PloS one 2010-02, Vol.5 (2), p.e9436-e9436
Main Authors: Rodríguez-García, Marta, Climent, Núria, Oliva, Harold, Casanova, Víctor, Franco, Rafael, Leon, Agathe, Gatell, José M, García, Felipe, Gallart, Teresa
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adult
AIDS
alpha-Defensins - blood
alpha-Defensins - genetics
alpha-Defensins - metabolism
Antimicrobial peptides
Antiretroviral agents
Antiretroviral drugs
Antiviral activity
CD4 antigen
CD4 Lymphocyte Count
Cells, Cultured
Controllers
Defensins
Dendritic cells
Dendritic Cells - cytology
Dendritic Cells - immunology
Dendritic Cells - metabolism
Diagnostic systems
Disease Progression
Disease transmission
Enzyme-Linked Immunosorbent Assay
Female
Flow Cytometry
Gene Expression
Genomics
HIV
HIV (Viruses)
HIV Infections - blood
HIV Infections - immunology
HIV Infections - pathology
Human immunodeficiency virus
Humans
Immunologia
Immunology
Immunology/Immunity to Infections
Immunology/Innate Immunity
Immunophenotyping
Infectious Diseases/HIV Infection and AIDS
Internalization
Lymphocytes
Lymphocytes T
Male
Middle Aged
Monocytes
Monocytes - cytology
Patients
Peptides
Protein Isoforms - blood
Protein Isoforms - genetics
Reverse Transcriptase Polymerase Chain Reaction
Statistical analysis
T cell receptors
VIH (Virus)
Virions
Citations: Items that cite this one
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Summary:Defensins are natural endogenous antimicrobial peptides with potent anti-HIV activity and immuno-modulatory effects. We recently demonstrated that immature dendritic cells (DC) produce alpha-defensins1-3 and that alpha-defensins1-3 modulate DC generation and maturation. Since DC-HIV interaction plays a critical role during the first steps of HIV infection, we investigated the possible impact of alpha-defensins1-3 production by DC on disease progression. Monocyte-derived DC (MDDC) were analyzed comparatively in healthy controls (HC) and HIV-infected patients, including untreated "elite" and "viremic" controllers, untreated viremic non-controllers and antiretroviral-treated patients. We found that production of alpha-defensins1-3 was significantly increased in MDDC from HIV-infected patients versus HC, and this increase was mainly due to that observed in controllers, while in non-controllers the increase was not statistically significant (controllers vs. HC, p
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0009436