Streptococcus suis, an Important Cause of Adult Bacterial Meningitis in Northern Vietnam

Background: Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection...

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Bibliographic Details
Published in:	PloS one 2009-06, Vol.4 (6), p.e5973-e5973
Main Authors:	Wertheim, Heiman F.L, Nguyen, Huyen Nguyen, Taylor, Walter, Lien, Trinh Thi Minh, Ngo, Hoa Thi, Nguyen, Thai Quoc, Nguyen, Bich Ngoc Thi, Nguyen, Ha Hong, Nguyen, Ha Minh, Nguyen, Cap Trung, Dao, Trinh Tuyet, Nguyen, Trung Vu, Fox, Annette, Farrar, Jeremy, Schultsz, Constance, Nguyen, Hien Duc
Format:	Article
Language:	eng
Subjects:	Adolescent Adult Adults Aged Animals Bacteria bacterial infections Bacterial meningitis Blood Blood culture Cerebrospinal fluid Clinical medicine Critical care Disease disease diagnosis disease transmission Disseminated infection epidemiology Farmers Female Hogs Hospitals human diseases Humans Infection Infections Infectious Diseases Infectious Diseases/Bacterial Infections Infectious Diseases/Infectious Diseases of the Nervous System Male Medical examination Medical referrals Medicine Meningitis Meningitis, Bacterial - epidemiology Meningitis, Bacterial - microbiology Middle Aged Pathogens Patients Polymerase Chain Reaction Pork industry Sepsis Sequence Analysis, DNA Streptococcal Infections - epidemiology Streptococcal Infections - microbiology Streptococcus Streptococcus suis Streptococcus suis - metabolism Suidae Swine Tropical diseases Vietnam Zoonoses
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Summary:	Background: Streptococcus suis can cause severe systemic infection in adults exposed to infected pigs or after consumption of undercooked pig products. S. suis is often misdiagnosed, due to lack of awareness and improper testing. Here we report the first fifty cases diagnosed with S. suis infection in northern Viet Nam. Methodology/Principal Findings: In 2007, diagnostics for S. suis were set up at a national hospital in Hanoi. That year there were 43 S. suis positive cerebrospinal fluid samples, of which S. suis could be cultured in 32 cases and 11 cases were only positive by PCR. Seven patients were blood culture positive for S. suis but CSF culture and PCR negative; making a total of 50 patients with laboratory confirmed S. suis infection in 2007. The number of S. suis cases peaked during the warmer months. Conclusions/Significance: S. suis was commonly diagnosed as a cause of bacterial meningitis in adults in northern Viet Nam. In countries where there is intense and widespread exposure of humans to pigs, S. suis can be an important human pathogen.
ISSN:	1932-6203 1932-6203