DNA watermarking of infectious agents: progress and prospects

  [...]pathogen-specific SOPs must be developed, keeping in mind the need for transparency and collaboration in research, and tested in a "role playing" scenario. [...]convincingly establishing phenotypic neutrality of genomic modifications will be non-trivial, and thus, will constitute an...

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Bibliographic Details
Published in:PLoS pathogens 2010-06, Vol.6 (6), p.e1000950-e1000950
Main Authors: Jupiter, Daniel C, Ficht, Thomas A, Samuel, James, Qin, Qing-Ming, de Figueiredo, Paul
Format: Article
Language:English
Subjects:
Animals
Biotechnology
Communicable Diseases - diagnosis
Communicable Diseases - genetics
DNA
DNA - genetics
Genomes
Humans
Infectious Diseases
Inventory control
Laboratories
Liability
Microbiology
Opinion
Organisms
Pattern Recognition, Automated
Physiological aspects
Polymerase chain reaction
Science Policy
Studies
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Summary:  [...]pathogen-specific SOPs must be developed, keeping in mind the need for transparency and collaboration in research, and tested in a "role playing" scenario. [...]convincingly establishing phenotypic neutrality of genomic modifications will be non-trivial, and thus, will constitute an important area for future research. Despite these potential impediments, watermarking would nearly eliminate the potential for mistaken assignment of source for a suspected agent release. [...]the development and implementation costs may prove to be much less than other proposed measures for enhancing laboratory security, including around-the-clock security patrols.
ISSN:1553-7374
1553-7366
1553-7374
DOI:10.1371/journal.ppat.1000950