Correlation of atrophy measures on MRI with neuropsychological sequelae in children and adolescents with traumatic brain injury

To examine the relationship between neuropsychological sequelae and atrophy parameters from magnetic resonance imaging (MRI) following paediatric moderate-to-severe traumatic brain injury (TBI), 19 head-injured children and adolescents were studied at least 6 years after injury. Three-dimensional MR...

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Bibliographic Details
Published in:Brain injury 2001-03, Vol.15 (3), p.211-221
Main Authors: VERGER, K, JUNQUE, C, LEVIN, H. S, JURADO, M. A, PEREZ-GOMEZ, M, BARTRES-FAZ, D, BARRIOS, M, ALVAREZ, A, BARTUMEUS, F, MERCADER, J. M
Format: Article
Language:English
Subjects:
Adolescent
Adult
Atrophy
Biological and medical sciences
Brain - pathology
Brain Damage, Chronic - diagnosis
Brain Damage, Chronic - psychology
Brain Injury, Chronic - diagnosis
Brain Injury, Chronic - psychology
Cerebral Ventricles - pathology
Child
Child, Preschool
Corpus Callosum - pathology
Female
Follow-Up Studies
Humans
Image Processing, Computer-Assisted
Injuries of the nervous system and the skull. Diseases due to physical agents
Magnetic Resonance Imaging
Male
Medical sciences
Neuropsychological Tests
Reference Values
Traumas. Diseases due to physical agents
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Summary:To examine the relationship between neuropsychological sequelae and atrophy parameters from magnetic resonance imaging (MRI) following paediatric moderate-to-severe traumatic brain injury (TBI), 19 head-injured children and adolescents were studied at least 6 years after injury. Three-dimensional MRI scans were obtained. A semi-automatic computerized method was used to estimate ventricular volumes and the corpus callosum area. Tests of intellectual, memory, visuospatial, frontal lobe, and motor speed functioning were administered to all patients and to 19 matched normal control subjects. Patients' performance significantly differed from controls in general intellectual function, visual memory, visuospatial and frontal lobe tests. The corpus callosum area correlated strongly with several measures involving processing speed and visuospatial function. Ventricular enlargement was less related to neuropsychological outcome. In conclusion, quantitative measurement of the corpus callosum on MRI reflects neuropsychological outcome better than ventricular dilation in paediatric patients.
ISSN:0269-9052
1362-301X
DOI:10.1080/02699050010004059