Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport

Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport. Diabetic nephropathy is more common in patients with a positive family history of hypertension and with elevated red blood cell sodium-lithium countertransport, a marker of risk for esse...

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Bibliographic Details
Published in:Kidney international 1992-04, Vol.41 (4), p.855-861
Main Authors: Trevisan, Roberto, Nosadini, Romano, Fioretto, Paola, Semplicini, Andrea, Donadon, Valter, Doria, Alessandro, Nicolosi, Gianluca, Zanuttini, Danilo, Cipollina, Maria Rita, Lusiani, Luigi, Avogaro, Angelo, Crepaldi, Gaetano, Viberti, GianCarlo
Format: Article
Language:English
Subjects:
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Biological and medical sciences
Carrier Proteins - metabolism
Diabetes Mellitus, Type 1 - blood
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - metabolism
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose - metabolism
Glucose Clamp Technique
Humans
Hypertension - complications
Life Sciences & Biomedicine
Lipids - blood
Medical sciences
Risk Factors
Science & Technology
Sodium - blood
Urology & Nephrology
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Summary:Clustering of risk factors in hypertensive insulin-dependent diabetics with high sodium-lithium countertransport. Diabetic nephropathy is more common in patients with a positive family history of hypertension and with elevated red blood cell sodium-lithium countertransport, a marker of risk for essential hypertension. To evaluate whether there is a relationship between this cation transport system and indicators of risk of renal and cardiovascular complications in diabetic patients before the development of clinical proteinuria, we studied 31 type 1 (insulin-dependent) diabetic patients with arterial hypertension, without clinical proteinuria and 12 normotensive normoalbuminuric diabetic patients. Sodium-lithium countertransport activity was significantly higher in hypertensive patients (0.43 ± 0.03 mmol/1 RBC x hr) than in normotensive patients (0.23 ± 0.03; P < 0.001). To better explore the nature of the association between this transport system and arterial hypertension, hypertensive patients were divided in two groups, with high (>0.41 mmol/1 RBC x hr) or normal (
ISSN:0085-2538
1523-1755
DOI:10.1038/ki.1992.131