Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy

In adult mammals, injured axons regrow over long distances in peripheral nerves but fail to do so in the central nervous system. Analysis of molecular components of tissue environments that allow axonal regrowth revealed a dramatic increase in the level of hemopexin, a heme-transporting protein, in...

Full description

Saved in:
Bibliographic Details
Published in:The Journal of biological chemistry 1992-05, Vol.267 (15), p.10596-10600
Main Authors: SWERTS, JP, SOULA, C, SAGOT, Y, GUINAUDY, MJ, GUILLEMOT, JC, FERRARA, P, DUPRAT, AM, COCHARD, P
Format: Article
Language:English
Subjects:
accumulation
Amino Acid Sequence
Analytical, structural and metabolic biochemistry
Animals
Axons - physiology
axotomy
Biochemistry & Molecular Biology
Biological and medical sciences
Blotting, Western
central nervous system
Central Nervous System - metabolism
Electrophoresis, Polyacrylamide Gel
Female
Fluorescent Antibody Technique
Fundamental and applied biological sciences. Psychology
hemopexin
Hemopexin - biosynthesis
Life Sciences & Biomedicine
Male
Miscellaneous
Molecular Sequence Data
peripheral nerves
Proteins
Rats
Rats, Inbred Strains
Regeneration
Sciatic Nerve - metabolism
Sciatic Nerve - surgery
Science & Technology
synthesis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In adult mammals, injured axons regrow over long distances in peripheral nerves but fail to do so in the central nervous system. Analysis of molecular components of tissue environments that allow axonal regrowth revealed a dramatic increase in the level of hemopexin, a heme-transporting protein, in long-term axotomized peripheral nerve. In contrast, hemopexin did not accumulate in lesioned optic nerve. Sciatic nerve and skeletal muscle, but not brain, were shown to be sites of synthesis of hemopexin. Thus, hemopexin expression, which can no longer be considered to be liver-specific, correlates with tissular permissivity for axonal regeneration.
ISSN:0021-9258
1083-351X
DOI:10.1016/S0021-9258(19)50058-8