Effects of Insulin on Renal Sodium Excretion

The ability of insulin to decrease urinary sodium excretion has been recognized for more than 30 years. While most investigators agree that this occurs predominantly through increased tubular sodium reabsorption, the nephron segments at which insulin exerts this effect in vivo remain controversial....

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Bibliographic Details
Published in:Hypertension (Dallas, Tex. 1979) Tex. 1979), 1992-01, Vol.19 (1 Suppl I), p.I-78-I-82
Main Authors: Gupta, Akshey K, Clark, Roderick V, Kirchner, Kent A
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cardiovascular System & Cardiology
Fundamental and applied biological sciences. Psychology
Humans
Insulin - pharmacology
Kidney - drug effects
Kidney - metabolism
Life Sciences & Biomedicine
Natriuresis - drug effects
Peripheral Vascular Disease
Science & Technology
Sodium - urine
Vertebrates: urinary system
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Summary:The ability of insulin to decrease urinary sodium excretion has been recognized for more than 30 years. While most investigators agree that this occurs predominantly through increased tubular sodium reabsorption, the nephron segments at which insulin exerts this effect in vivo remain controversial. Additionally, little information is available in mammalian systems on the mechanism of the insulin response or its relation to other hormonal systems important in the regulation of tubular sodium transport. Data from amphibian transporting epithelia suggest a potential for interactions between insulin and several other pcptide hormones in the regulation of sodium transport. The following discussion attempts to review our knowledge of the effects of insulin on renal sodium reabsorption and describes new data suggesting that insulinʼs antinatriuretic response is dependent on antidiuretic hormone but independent of the angiotensin and prostaglandin systems.
ISSN:0194-911X
1524-4563
DOI:10.1161/01.hyp.19.1_suppl.i78