VIREMIC PHASE IN A LEUKEMIC CHILD AFTER LIVE VARICELLA VACCINATION

Live varicella vaccine has been shown to be efficacious for prevention of varicella even in immunocompromised children.1-4 Although the site and extent of viral replication in vaccinated hosts have not been fully defined, vaccinees have developed humoral and cellular immunity.1-5 A viremic phase has...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1992-01, Vol.89 (1), p.147-149
Main Authors: IHARA, T, KAMIYA, H, TORIGOE, S, SAKURAI, M, TAKAHASHI, M
Format: Article
Language:English
Subjects:
Biological and medical sciences
Causes of
Chickenpox
Chickenpox Vaccine
Chickenpox vaccines
Child, Preschool
Childhood leukemia
Female
Health aspects
Hepatitis, Viral, Human - etiology
Herpesvirus 3, Human - immunology
Human viral diseases
Humans
Immune Tolerance
Infectious diseases
Leukemia in children
Life Sciences & Biomedicine
Medical sciences
Pediatrics
Physiological aspects
Precursor Cell Lymphoblastic Leukemia-Lymphoma - immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma - microbiology
Science & Technology
Skin Diseases, Vesiculobullous - etiology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Viral Vaccines - adverse effects
Viremia - etiology
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Summary:Live varicella vaccine has been shown to be efficacious for prevention of varicella even in immunocompromised children.1-4 Although the site and extent of viral replication in vaccinated hosts have not been fully defined, vaccinees have developed humoral and cellular immunity.1-5 A viremic phase has been demonstrated in immunocompromised and normal children with natural varicella.6,7 However, a viremic phase has not been reported in vaccinated children. We report our observation of viremia in a leukemic child in whom vesicles and hepatitis developed after live varicella vaccination. MATERIALS AND METHODS Human embryonic lung fibroblasts (HEFs) were used for virus isolation. The cells were grown in 25-cm2 plastic tissue culture flasks containing Eagle's minimal essential medium with 7.5% fetal bovine serum.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.89.1.147