Effects of the serotonin transporter polymorphism and history of major depression on overgeneral autobiographical memory

Overgeneral autobiographical memory (OGM) is a key memory deficit in major depressive disorder (MDD). Much research has examined cognitive mechanisms underlying OGM, but little work has investigated potential neurobiological influences. There is preliminary evidence that a genetic serotonergic vulne...

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Bibliographic Details
Published in:Cognition and emotion 2014-07, Vol.28 (5), p.947-958
Main Authors: Sumner, Jennifer A., Vrshek-Schallhorn, Suzanne, Mineka, Susan, Zinbarg, Richard E., Craske, Michelle G., Redei, Eva E., Wolitzky-Taylor, Kate, Adam, Emma K.
Format: Article
Language:English
Subjects:
5-HTTLPR
Adult
Adult and adolescent clinical studies
Alleles
Autobiographical memory
Autobiographical memory specificity
Biological and medical sciences
Depression
Depressive Disorder, Major - complications
Depressive Disorder, Major - genetics
Depressive Disorder, Major - psychology
Depressive personality disorders
Female
Genetic association
Humans
Longitudinal Studies
Male
Medical sciences
Memory
Memory Disorders - complications
Memory Disorders - genetics
Memory Disorders - psychology
Memory, Episodic
Mood disorders
Overgeneral autobiographical memory
Polymorphism, Genetic - genetics
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Risk Factors
Serotonin
Serotonin Plasma Membrane Transport Proteins - genetics
Young Adult
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Summary:Overgeneral autobiographical memory (OGM) is a key memory deficit in major depressive disorder (MDD). Much research has examined cognitive mechanisms underlying OGM, but little work has investigated potential neurobiological influences. There is preliminary evidence that a genetic serotonergic vulnerability coupled with depressive symptoms may be associated with other memory impairments, and experimental research suggests a role for serotonin in OGM. We investigated whether a polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) was associated with OGM in interaction with a lifetime history of MDD in 370 young adults in a longitudinal study of risk for emotional disorders. There was a significant interaction between 5-HTTLPR genotype and lifetime history of MDD in predicting OGM. Among S allele homozygotes, MDD history was associated with greater OGM, whereas no significant relationship between MDD history and OGM emerged among L carriers. Furthermore, there was evidence that a greater number of S alleles were associated with greater memory specificity in individuals without a history of MDD. Implications for understanding cognitive and biological risk for depression are discussed.
ISSN:0269-9931
1464-0600
DOI:10.1080/02699931.2013.865596