Gastritis Classified in Accordance with the Sydney System in Patients with Primary Sjögren's Syndrome

Background: According to some earlier reports, chronic atrophic gastritis is a common finding in Sjögren's syndrome. However, the findings are controversial. The aim of this study was to investigate the occurrence of gastritis classified in accordance with the Sydney System in patients with pri...

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Bibliographic Details
Published in:Scandinavian journal of gastroenterology 1997, Vol.32 (2), p.108-111
Main Authors: Collin, P., Karvonen, A. L., Korpela, M., Laippala, P., Helin, H.
Format: Article
Language:English
Subjects:
Adult
Aged
Atrophy
Biological and medical sciences
Biopsy
Dyspepsia
Female
Gastritis
Gastritis - complications
Gastritis - microbiology
Gastritis - pathology
Helicobacter Infections - complications
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - isolation & purification
Humans
Inflammation
Male
Medical sciences
Middle Aged
Non tumoral diseases
Otorhinolaryngology. Stomatology
Sjogren's Syndrome - complications
Sjogren's Syndrome - pathology
Sjögren's syndrome
Stomach - pathology
Sydney System
Upper respiratory tract, upper alimentary tract, paranasal sinuses, salivary glands: diseases, semeiology
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Summary:Background: According to some earlier reports, chronic atrophic gastritis is a common finding in Sjögren's syndrome. However, the findings are controversial. The aim of this study was to investigate the occurrence of gastritis classified in accordance with the Sydney System in patients with primary Sjögren's syndrome. Methods: Thirty-two consecutive patients (27 women, 5 men) with primary Sjögren's syndrome, and 64 age-and sex-matched control subjects with dyspepsia underwent gastroscopic examination. Mucosal biopsy specimens were taken from the gastric antrum and corpus. Results: Eight (25%) patients with Sjögren's syndrome and three (4.1%) control subjects had atrophic antral gastritis (P = 0.01). Atrophic corpus gastritis was more frequently found in control subjects, but the difference was not statistically significant. None of the subjects had severe (grade 3) atrophy. Gastric inflammation, in either the corpus or antrum, was found in 85% of patients with Sjögren's syndrome and in 61% of control subjects (P = 0.02). Helicobacter pylori was present in 31% of Sjögren's syndrome patients and in 39% of controls (NS). Conclusions: In patients with primary Sjögren's syndrome mild atrophic changes in the antrum were common, but severe mucosal atrophy was rare. Compared with control subjects, gastric inflammation was seen more often in patients with Sjögren's syndrome.
ISSN:0036-5521
1502-7708
DOI:10.3109/00365529709000179