Effect of N-acetylcystein on pulmonary function in patients undergoing off-pump coronary artery bypass surgery

Background: Pulmonary dysfunction related to inflammatory response and radical oxygen species remains a problem in off‐pump coronary bypass graft surgery (OPCAB), especially in patients with reduced left ventricular (LV) function. The aim of this study was to evaluate the effect of N‐acetylcystein (...

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Bibliographic Details
Published in:Acta anaesthesiologica Scandinavica 2011-04, Vol.55 (4), p.452-459
Main Authors: KIM, J.-C., HONG, S.-W., SHIM, J.-K., YOO, K.-J., CHUN, D.-H., KWAK, Y.-L.
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Biological and medical sciences
Medical sciences
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Summary:Background: Pulmonary dysfunction related to inflammatory response and radical oxygen species remains a problem in off‐pump coronary bypass graft surgery (OPCAB), especially in patients with reduced left ventricular (LV) function. The aim of this study was to evaluate the effect of N‐acetylcystein (NAC) on pulmonary function following OPCAB. Methods: Patients with LV ejection fraction ≤40% were randomly assigned to receive either a bolus of 100 mg/kg of intravenous NAC over a 15‐min period immediately after anesthetic induction, followed by an intravenous infusion at 40 mg/kg/day for 24 h (NAC group, n=24), or a placebo (control group, n=24). Hemodynamic and pulmonary parameters, and the incidence of acute lung injury (PaO2/FiO2
ISSN:0001-5172
1399-6576
DOI:10.1111/j.1399-6576.2011.02407.x