COMT Val 158Met polymorphism is related with interpersonal problem solving in schizophrenia

The aim of this study was to investigate associations between COMT Val 158Met polymorphism, and interpersonal problem solving capacity and cognitive functions in schizophrenia. COMT Val 158Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. Brief Psychiatric Ratin...

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Bibliographic Details
Published in:European psychiatry 2010, Vol.25 (6), p.320-322
Main Authors: Üçok, A., Öztürk, M., Duman, Z., Saruhan-Direskeneli, G.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Attention
Biological and medical sciences
Cognition
COMT Val 158Met
Interpersonal problem solving
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
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Summary:The aim of this study was to investigate associations between COMT Val 158Met polymorphism, and interpersonal problem solving capacity and cognitive functions in schizophrenia. COMT Val 158Met polymorphism was studied with ARMS-PCR method in 99 outpatients with schizophrenia. Brief Psychiatric Rating Scale was used to assess symptom severity. The Assessment of Interpersonal Problem Solving Skills (AIPSS) was used to evaluate problem solving capacity. Continuous Performance Test (CPT) and Wisconsin Card Sorting Test (WCST), were used to measure cognition. Patients with Met/Met genotype had higher AIPSS subscores for detecting the problem, than those with Val/Val at baseline ( p = 0.02). Met allele was also found to be related with higher AIPSS-receiving skills ( p = 0.04). Val allele was found to be related with more commission errors in CPT ( p = 0.03). There was no relation between Val 158Met polymorphism and WCST and clinical measurements. Our findings suggest that Val allele might be related to poor performance on detecting the interpersonal problems, and attention in schizophrenia.
ISSN:0924-9338
1778-3585
DOI:10.1016/j.eurpsy.2010.01.012