Serological Monitoring of Progression of Alveolar Echinococcosis with Multiorgan Involvement by Use of Recombinant Em18

Two cases of alveolar echinococcosis (AE) with multiple-organ involvement (the liver, lungs, and bone) were monitored by imaging and serology for 20 years. Resection of the bone lesion was complete in one case but incomplete in the other case. Albendazole treatment was markedly to moderately effecti...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2009-10, Vol.47 (10), p.3191-3196
Main Authors: Ishikawa, Yuji, Sako, Yasuhito, Itoh, Sonoyo, Ohtake, Takaaki, Kohgo, Yutaka, Matsuno, Takeo, Ohsaki, Yoshinobu, Miyokawa, Naoyuki, Nakao, Minoru, Nakaya, Kazuhiro, Ito, Akira
Format: Article
Language:English
Subjects:
Adult
Albendazole - therapeutic use
Animals
Anthelmintics - therapeutic use
Antibodies, Helminth - blood
Antigens, Helminth
Biological and medical sciences
Bone and Bones - parasitology
Bone and Bones - pathology
Diseases caused by cestodes
Echinococcoses
Echinococcosis - immunology
Echinococcosis - pathology
Echinococcus - immunology
Enzyme-Linked Immunosorbent Assay - methods
Female
Fundamental and applied biological sciences. Psychology
Helminthic diseases
Humans
Immunoglobulin G - blood
Infectious diseases
Liver - parasitology
Liver - pathology
Lung - parasitology
Lung - pathology
Medical sciences
Microbiology
Parasitic diseases
Parasitology
Treatment Outcome
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Description
Summary:Two cases of alveolar echinococcosis (AE) with multiple-organ involvement (the liver, lungs, and bone) were monitored by imaging and serology for 20 years. Resection of the bone lesion was complete in one case but incomplete in the other case. Albendazole treatment was markedly to moderately effective against hepatic and pulmonary AE lesions in both cases, whereas it had almost no effect against the bone lesion in one case. The results of the serological tests with recombinant Em18 antigen coincided with the clinical findings in each case. An enzyme-linked immunosorbent assay for the detection of immunoglobulin G (IgG) responses, especially IgG4 responses, is expected to be a real-time indicator of the dynamics of active AE.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01111-09