Dynamics of the Mucosa-Associated Flora in Ulcerative Colitis Patients during Remission and Clinical Relapse

The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness tow...

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Bibliographic Details
Published in:Journal of Clinical Microbiology 2008-10, Vol.46 (10), p.3510-3513
Main Authors: Ott, Stephan J, Plamondon, Sophie, Hart, Ailsa, Begun, Alexander, Rehman, Ateequr, Kamm, Michael A, Schreiber, Stefan
Format: Article
Language:English
Subjects:
Adult
Bacteriology
Biodiversity
Biological and medical sciences
Colitis, Ulcerative - microbiology
Colitis, Ulcerative - prevention & control
Colon - microbiology
DNA, Bacterial - chemistry
DNA, Bacterial - genetics
DNA, Ribosomal - chemistry
DNA, Ribosomal - genetics
Female
Fundamental and applied biological sciences. Psychology
Humans
Intestinal Mucosa - microbiology
Male
Microbiology
Middle Aged
Phylogeny
Recurrence
RNA, Ribosomal, 16S - genetics
Sequence Analysis, DNA
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Summary:The colonic mucosa-associated flora (MAF) in patients with active ulcerative colitis (UC) (n = 13) was investigated by examining 16S rRNA gene signatures during remission and relapse against levels for controls (n = 5). Baseline reduction, temporal instability, and decrease of bacterial richness toward relapse were observed for UC patients, whereas the MAF for controls was stable over time.
ISSN:0095-1137
1098-660X
DOI:10.1128/JCM.01512-08