Effects of exercise intensity on salivary antimicrobial proteins and markers of stress in active men

In the present study, we assessed the effects of exercise intensity on salivary immunoglobulin A (s-IgA) and salivary lysozyme (s-Lys) and examined how these responses were associated with salivary markers of adrenal activation. Using a randomized design, 10 healthy active men participated in three...

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Bibliographic Details
Published in:Journal of sports sciences 2008-04, Vol.26 (6), p.653-661
Main Authors: Allgrove, Judith E., Gomes, Elisa, Hough, John, Gleeson, Michael
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
chromogranin A
Chromogranin A - metabolism
Cohort Studies
Exercise - physiology
exercise intensity
Exercise Test
Fundamental and applied biological sciences. Psychology
Humans
immunoglobulin A
Immunoglobulin A - metabolism
lysozyme
Male
Muramidase - metabolism
Saliva - chemistry
Saliva - metabolism
Saliva flow rate
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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Summary:In the present study, we assessed the effects of exercise intensity on salivary immunoglobulin A (s-IgA) and salivary lysozyme (s-Lys) and examined how these responses were associated with salivary markers of adrenal activation. Using a randomized design, 10 healthy active men participated in three experimental cycling trials: 50% maximal oxygen uptake ([Vdot]O 2max ), 75%[Vdot]O 2max , and an incremental test to exhaustion. The durations of the trials were the same as for a preliminary incremental test to exhaustion (22.3 min, s x  = 0.8). Timed, unstimulated saliva samples were collected before exercise, immediately after exercise, and 1 h after exercise. In the incremental exhaustion trial, the secretion rates of both s-IgA and s-Lys were increased. An increase in s-Lys secretion rate was also observed at 75%[Vdot]O 2max . No significant changes in saliva flow rate were observed in any trial. Cycling at 75%[Vdot]O 2max and to exhaustion increased the secretion of α-amylase and chromogranin A immediately after exercise; higher cortisol values at 75%[Vdot]O 2max and in the incremental exhaustion trial compared with 50%[Vdot]O 2max were observed 1 h immediately after exercise only. These findings suggest that short-duration, high-intensity exercise increases the secretion rate of s-IgA and s-Lys despite no change in the saliva flow rate. These effects appear to be associated with changes in sympathetic activity and not the hypothalamic - pituitary - adrenal axis.
ISSN:0264-0414
1466-447X
DOI:10.1080/02640410701716790