Study of the nature of recognition in molecularly imprinted polymers, II : Influence of monomer–template ratio and sample load on retention and selectivity

To investigate the extent and nature of the monomer–template association of molecularly imprinted polymer pre-polymerisation mixtures, a series of (−)-nicotine molecularly imprinted acrylic polymers was prepared using a range of monomer–template molar ratios. Load capacity studies performed in the c...

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Bibliographic Details
Published in:Journal of Chromatography A 1999-07, Vol.848 (1), p.39-49
Main Authors: Andersson, Håkan S, Karlsson, Jesper G, Piletsky, Sergey A, Koch-Schmidt, Ann-Christin, Mosbach, Klaus, Nicholls, Ian A
Format: Article
Language:English
Subjects:
Analytical chemistry
Chemistry
Chromatographic methods and physical methods associated with chromatography
Exact sciences and technology
Nicotine
Other chromatographic methods
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Summary:To investigate the extent and nature of the monomer–template association of molecularly imprinted polymer pre-polymerisation mixtures, a series of (−)-nicotine molecularly imprinted acrylic polymers was prepared using a range of monomer–template molar ratios. Load capacity studies performed in the chromatographic mode showed an unexpected increase in retention at higher nicotine sample loads. Further analyses of this effect indicate that solvation effects, and potentially the presence of higher order template complexes, may explain this behaviour. The implications of these results are discussed in terms of the current model for molecular imprinting, and it is suggested that the possibility of template self-association should be included in this model.
ISSN:0021-9673
DOI:10.1016/S0021-9673(99)00483-5