Subcutaneous administration of collagen-polyvinylpyrrolidone down regulates IL-1β, TNF-α, TGF-β1, ELAM-1 and VCAM-1 expression in scleroderma skin lesions

Summary In this study the effect of collagen‐polyvinylpyrrolidone (collagen‐PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous injections of 0.2 mL Triam (8 mg/mL) or 0.2 mL collagen‐PVP (1.66 mg collagen)....

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Bibliographic Details
Published in:Clinical and experimental dermatology 2005-01, Vol.30 (1), p.83-86
Main Authors: Furuzawa-Carballeda, J., Krötzsch, E., Barile-Fabris, L., Alcalá, M., Espinosa-Morales, R.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Medical sciences
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
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Summary:Summary In this study the effect of collagen‐polyvinylpyrrolidone (collagen‐PVP) vs. triamcinolone acetonide (Triam) in scleroderma (SSc) skin lesions was evaluated. Ten SSc patients were treated weekly with subcutaneous injections of 0.2 mL Triam (8 mg/mL) or 0.2 mL collagen‐PVP (1.66 mg collagen). Skin biopsies were obtained from lesions before and after treatment. Tissue sections were evaluated by histology and immunohistochemistry (ELAM‐1, VCAM‐1, IL‐1β, TNF‐α, TGF‐β1 and PDGF). The corticoid‐treated group showed abnormal tissue architecture while the biodrug‐treatment restored cutaneous appendages and type I/III collagen proportion. Cytokine and adhesion molecule expression was almost inhibited with Triam, while collagen‐PVP down‐regulated it. Collagen‐PVP improved the tissue architecture of SSc lesions and down‐regulated some proinflammatory parameters, without the side effects induced by corticoids.
ISSN:0307-6938
1365-2230
DOI:10.1111/j.1365-2230.2004.01691.x