Upper airway afferents are sufficient to evoke the early components of respiratory-related cortical potentials in humans

1 Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 2 Unité Propre de Recherche de l'Enseignement Supérieur EA 2397, Université Pierre et Marie Curie Paris VI, 3 Service Central d'Explorations...

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Published in:Journal of applied physiology (1985) 2004-11, Vol.97 (5), p.1874-1879
Main Authors: Donzel-Raynaud, Christine, Straus, Christian, Bezzi, Michela, Redolfi, Stefania, Raux, Mathieu, Zelter, Marc, Derenne, Jean-Philippe, Similowski, Thomas
Format: Article
Language:English
Subjects:
Adult
Air breathing
Biological and medical sciences
Brain
Cerebral Cortex - physiopathology
Cognition & reasoning
Denervation
Evoked Potentials, Somatosensory
Female
Fundamental and applied biological sciences. Psychology
Humans
Male
Middle Aged
Mouth - innervation
Neurons, Afferent
Respiration
Respiratory Insufficiency - physiopathology
Respiratory Insufficiency - surgery
Respiratory Paralysis - physiopathology
Respiratory Paralysis - surgery
Respiratory system
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Trachea - innervation
Tracheotomy
Vertebrates: respiratory system
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Summary:1 Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 2 Unité Propre de Recherche de l'Enseignement Supérieur EA 2397, Université Pierre et Marie Curie Paris VI, 3 Service Central d'Explorations Fonctionnelles Respiratoires, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux de Paris, 75013 Paris, France, and 4 Servizio di Medicina Interna 1, Spedali Civili, and Universita di Brescia, Brescia 25100, Italy Submitted 22 December 2003 ; accepted in final form 24 June 2004 Repeated inspiratory occlusions in humans elicit respiratory-related cortical potentials, the respiratory counterpart of somatosensory-evoked potentials. These potentials comprise early components (stimulus detection) and late components (cognitive processing). They are considered as the summation of several afferent activities from various part of the respiratory system. This study assesses the role of the upper airway as a determinant of the early and late components of the potentials, taking advantage of the presence of a tracheotomy in patients totally or partially deafferented. Eight patients who could breathe either through the mouth or through a tracheotomy orifice (whole upper airway bypassed) were studied (4 quadriplegic patients with phrenic pacing, 4 patients with various sources of inspiratory pump dysfunction). Respiratory-related evoked potentials were recorded in C Z -C 3 and C Z -C 4 . They were consistently present after mouth occlusions, with a first positive P1 and a first negative N1 components of normal latencies (P1: 40.4 ± 6.1 ms in C Z -C 3 and 47.6 ± 7.6 ms in C Z -C 4 ; N1: 84.4 ± 27.1 ms in C Z -C 3 and 90.2 ± 17.4 ms in C Z -C 4 ) and amplitudes. Tracheal occlusions did not evoke any cortical activity. Therefore, in patients with inspiratory pump dysfunction, the activation of upper airway afferents is sufficient to produce the early components of the respiratory-related evoked cortical potentials. Per contra, in this setting, pulmonary afferents do not suffice to evoke these components. somatosensory evoked potentials; visceral afferents; respiratory sensations; dyspnea Address for reprint requests and other correspondence: T. Similowski, Laboratoire de Physiopathologie Respiratoire, Service de Pneumologie et de Réanimation, Groupe Hospitalier Pitié-Salpètriêre, 47-83, Bd de l'Hôpital, 75651 Paris Cedex 13, France (E-mail: thomas.similowski{at}psl.ap-hop
ISSN:8750-7587
1522-1601
DOI:10.1152/japplphysiol.01381.2003