Effects of Ovariectomy and Estrogen Replacement on Basal and Pelvic Nerve Stimulated Vaginal Lubrication in an Animal Model

The goal of this study was to investigate the effects of ovariectomy and estrogen replacement on vaginal tissue integrity and vaginal lubrication in basal conditions and in response to pelvic nerve stimulation (PNS). Two weeks after ovariectomy, female New Zealand White rabbits were administered veh...

Full description

Saved in:
Bibliographic Details
Published in:Journal of sex & marital therapy 2003-01, Vol.29 (sup1), p.77-84
Main Authors: MIN, KWEONSIK, MUNARRIZ, RICHARDO, KIM, NOEL M., CHOI, SEONG, O CONNELL, LUKE, GOLDSTEIN, IRWIN, TRAIS, ABDULMAGED M.
Format: Article
Language:English
Subjects:
Animals
Atrophy - pathology
Biological and medical sciences
Estrogen Replacement Therapy
Estrogens - metabolism
Female
Medical sciences
Ovariectomy
Pelvis - innervation
Peripheral Nerves - physiology
Postoperative Period
Rabbits
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgery of the genital tract and mammary gland
Vagina - metabolism
Vagina - pathology
Vagina - secretion
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The goal of this study was to investigate the effects of ovariectomy and estrogen replacement on vaginal tissue integrity and vaginal lubrication in basal conditions and in response to pelvic nerve stimulation (PNS). Two weeks after ovariectomy, female New Zealand White rabbits were administered vehicle or estradiol (200 g/day) for an additional 2 weeks. Ovariectomy caused significant vaginal atrophy and diminished vaginal lubrication in the basal state and after PNS, compared to intact controls. Estrogen replacement normalized lubrication values and tissue wet weight to control levels. In conclusion, vaginal tissue integrity and lubrication are diminished by ovariectomy and are normalized by estrogen replacement.
ISSN:0092-623X
1521-0715
DOI:10.1080/713847131